| http://purl.uniprot.org/citations/9275200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9275200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9275200 | http://www.w3.org/2000/01/rdf-schema#comment | "The het-s locus of Podospora anserina is a heterokaryon incompatibility locus. The coexpression of the antagonistic het-s and het-S alleles triggers a lethal reaction that prevents the formation of viable heterokaryons. Strains that contain the het-s allele can display two different phenotypes, [Het-s] or [Het-s*], according to their reactivity in incompatibility. The detection in these phenotypically distinct strains of a protein expressed from the het-s gene indicates that the difference in reactivity depends on a posttranslational difference between two forms of the polypeptide encoded by the het-s gene. This posttranslational modification does not affect the electrophoretic mobility of the protein in SDS/PAGE. Several results suggest a similarity of behavior between the protein encoded by the het-s gene and prions. The [Het-s] character can propagate in [Het-s*] strains as an infectious agent, producing a [Het-s*] --> [Het-s] transition, independently of protein synthesis. Expression of the [Het-s] character requires a functional het-s gene. The protein present in [Het-s] strains is more resistant to proteinase K than that present in [Het-s*] mycelium. Furthermore, overexpression of the het-s gene increases the frequency of the transition from [Het-s*] to [Het-s]. We propose that this transition is the consequence of a self-propagating conformational modification of the protein mediated by the formation of complexes between the two different forms of the polypeptide."xsd:string |
| http://purl.uniprot.org/citations/9275200 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.94.18.9773"xsd:string |
| http://purl.uniprot.org/citations/9275200 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.94.18.9773"xsd:string |
| http://purl.uniprot.org/citations/9275200 | http://purl.uniprot.org/core/author | "Begueret J."xsd:string |
| http://purl.uniprot.org/citations/9275200 | http://purl.uniprot.org/core/author | "Begueret J."xsd:string |
| http://purl.uniprot.org/citations/9275200 | http://purl.uniprot.org/core/author | "Deleu C."xsd:string |
| http://purl.uniprot.org/citations/9275200 | http://purl.uniprot.org/core/author | "Deleu C."xsd:string |
| http://purl.uniprot.org/citations/9275200 | http://purl.uniprot.org/core/author | "Coustou V."xsd:string |
| http://purl.uniprot.org/citations/9275200 | http://purl.uniprot.org/core/author | "Coustou V."xsd:string |
| http://purl.uniprot.org/citations/9275200 | http://purl.uniprot.org/core/author | "Saupe S."xsd:string |
| http://purl.uniprot.org/citations/9275200 | http://purl.uniprot.org/core/author | "Saupe S."xsd:string |
| http://purl.uniprot.org/citations/9275200 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9275200 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9275200 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/9275200 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/9275200 | http://purl.uniprot.org/core/pages | "9773-9778"xsd:string |
| http://purl.uniprot.org/citations/9275200 | http://purl.uniprot.org/core/pages | "9773-9778"xsd:string |
| http://purl.uniprot.org/citations/9275200 | http://purl.uniprot.org/core/title | "The protein product of the het-s heterokaryon incompatibility gene of the fungus Podospora anserina behaves as a prion analog."xsd:string |
| http://purl.uniprot.org/citations/9275200 | http://purl.uniprot.org/core/title | "The protein product of the het-s heterokaryon incompatibility gene of the fungus Podospora anserina behaves as a prion analog."xsd:string |
| http://purl.uniprot.org/citations/9275200 | http://purl.uniprot.org/core/volume | "94"xsd:string |
| http://purl.uniprot.org/citations/9275200 | http://purl.uniprot.org/core/volume | "94"xsd:string |
| http://purl.uniprot.org/citations/9275200 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9275200 |
| http://purl.uniprot.org/citations/9275200 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9275200 |