| http://purl.uniprot.org/citations/9282826 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9282826 | http://www.w3.org/2000/01/rdf-schema#comment | "The p17 matrix protein of the human immunodeficiency virus type 1 (HIV-1) plays a crucial role in AIDS pathogenesis. It orchestrates viral assembly and directs the preintegration complex to the nucleus of infected cells. Recently, the three-dimensional structure of p17 was shown to resemble that of interferon-gamma (IFN-gamma), suggesting that both proteins might share analogous functions. We demonstrate that in monocytes, p17 shares with IFN-gamma the ability to induce 1alpha-hydroxylase activity and to activate fructose 1,6-bisphosphatase gene expression in the presence of 25-hydroxyvitamin D3. However, p17 does not bind to the IFN-gamma cell membrane receptor and fails to increase expression of IFN-gamma-induced proteins, such as tryptophanyl-tRNA synthetase, Fc gammaRI, and HLA DR or B7/BB1 antigens. Altogether, our results raise the possibility that the structural resemblance between p17 and IFN-gamma causes the selective activation of a common pathway resulting in the production of 1,25-dihydroxyvitamin D3. We also found that unlike IFN-gamma, p17 increases the intracellular ATP content. Since transport of the HIV-1 preintegration complex through the nuclear membrane is an ATP-dependent process, our observation suggests that p17 plays a double role in this active transport, not only by acting as a chaperone molecule but also by recruiting the necessary energy for this process."xsd:string |
| http://purl.uniprot.org/citations/9282826 | http://purl.org/dc/terms/identifier | "doi:10.1089/jir.1997.17.461"xsd:string |
| http://purl.uniprot.org/citations/9282826 | http://purl.uniprot.org/core/author | "Solomon D."xsd:string |
| http://purl.uniprot.org/citations/9282826 | http://purl.uniprot.org/core/author | "Just J."xsd:string |
| http://purl.uniprot.org/citations/9282826 | http://purl.uniprot.org/core/author | "Cayre Y.E."xsd:string |
| http://purl.uniprot.org/citations/9282826 | http://purl.uniprot.org/core/author | "Besancon F."xsd:string |
| http://purl.uniprot.org/citations/9282826 | http://purl.uniprot.org/core/author | "Van Weyenbergh J."xsd:string |
| http://purl.uniprot.org/citations/9282826 | http://purl.uniprot.org/core/author | "Wietzerbin J."xsd:string |
| http://purl.uniprot.org/citations/9282826 | http://purl.uniprot.org/core/author | "Guillozo H."xsd:string |
| http://purl.uniprot.org/citations/9282826 | http://purl.uniprot.org/core/author | "Bourgeade M.F."xsd:string |
| http://purl.uniprot.org/citations/9282826 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9282826 | http://purl.uniprot.org/core/name | "J Interferon Cytokine Res"xsd:string |
| http://purl.uniprot.org/citations/9282826 | http://purl.uniprot.org/core/pages | "461-467"xsd:string |
| http://purl.uniprot.org/citations/9282826 | http://purl.uniprot.org/core/title | "HIV-1 p17 and IFN-gamma both induce fructose 1,6-bisphosphatase."xsd:string |
| http://purl.uniprot.org/citations/9282826 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/9282826 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9282826 |
| http://purl.uniprot.org/citations/9282826 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9282826 |
| http://purl.uniprot.org/uniprot/O15528#attribution-F66950E02CCB67F98568B0AD2301649C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9282826 |
| http://purl.uniprot.org/uniprot/P01579#attribution-F66950E02CCB67F98568B0AD2301649C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9282826 |
| http://purl.uniprot.org/uniprot/Q77YG1#attribution-98C05C50411A38BD9CB88DF39013F5DE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9282826 |
| http://purl.uniprot.org/uniprot/Q77YG1#attribution-F66950E02CCB67F98568B0AD2301649C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9282826 |