| http://purl.uniprot.org/citations/9286666 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9286666 | http://www.w3.org/2000/01/rdf-schema#comment | "During meiosis, axial elements are generated by the condensation of sister chromatids along a protein core as precursors to the formation of the synaptonemal complex (SC). Functional axial elements are essential for wild-type levels of recombination and proper reductional segregation at meiosis I. Genetic and cytological data suggest that three meiosis-specific genes, HOP1, RED1 and MEK1, are involved in axial element formation in the yeast Saccharomyces cerevisiae. HOP1 and RED1 encode structural components of axial elements while MEK1 encodes a putative protein kinase. Using a partially functional allele of MEK1, new genetic interactions have been found between HOP1, RED1 and MEK1. Overexpression of HOP1 partially suppresses the spore inviability and recombination defects of mek1-974; in contrast, overexpression of RED1 exacerbates the mek1-974 spore inviability. Co-overexpression of HOP1 and RED1 in mek1-974 diploids alleviates the negative effect of overexpressing RED1 alone. Red1p/Red1p as well as Hop1p/Red1p interactions have been reconstituted in two hybrid experiments. Our results suggest a model whereby Mek1 kinase activity controls axial element assembly by regulating the affinity with which Hop1p and Red1p interact with each other."xsd:string |
| http://purl.uniprot.org/citations/9286666 | http://purl.org/dc/terms/identifier | "doi:10.1093/genetics/147.1.33"xsd:string |
| http://purl.uniprot.org/citations/9286666 | http://purl.uniprot.org/core/author | "Hollingsworth N.M."xsd:string |
| http://purl.uniprot.org/citations/9286666 | http://purl.uniprot.org/core/author | "Ponte L."xsd:string |
| http://purl.uniprot.org/citations/9286666 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9286666 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/9286666 | http://purl.uniprot.org/core/pages | "33-42"xsd:string |
| http://purl.uniprot.org/citations/9286666 | http://purl.uniprot.org/core/title | "Genetic interactions between HOP1, RED1 and MEK1 suggest that MEK1 regulates assembly of axial element components during meiosis in the yeast Saccharomyces cerevisiae."xsd:string |
| http://purl.uniprot.org/citations/9286666 | http://purl.uniprot.org/core/volume | "147"xsd:string |
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| http://purl.uniprot.org/citations/9286666 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9286666 |
| http://purl.uniprot.org/uniprot/#_P20050-mappedCitation-9286666 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9286666 |
| http://purl.uniprot.org/uniprot/#_P14291-mappedCitation-9286666 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9286666 |
| http://purl.uniprot.org/uniprot/#_P24719-mappedCitation-9286666 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9286666 |
| http://purl.uniprot.org/uniprot/P14291 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9286666 |
| http://purl.uniprot.org/uniprot/P20050 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9286666 |
| http://purl.uniprot.org/uniprot/P24719 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9286666 |