| http://purl.uniprot.org/citations/9288975 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9288975 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9288975 | http://www.w3.org/2000/01/rdf-schema#comment | "Abnormal cells deficient in class I major histocompatibility complex (MHC) expression are lysed by a class of lymphocytes called natural killer (NK) cells. This lysis provides a defence against pathogens and tumour cells that downregulate MHC expression to avoid an MHC-restricted, T-cell immune response. Normal cells escape lysis because their MHC molecules are recognized by NK-cell inhibitory receptors, which inhibit lysis. Several such inhibitory receptor families have been described in humans and mice. In the human killer-cell inhibitory receptor family, individual p58 members are specific for a subset of class I human leukocyte antigen (HLA)-C molecules. The human p58 natural killer-cell inhibitory receptor clone 42 recognizes HLA-Cw4, -Cw2 and -Cw6, but not HLA-Cw3, -Cw2, -Cw7 or -Cw8, which are recognized by p58 killer-cell inhibitor receptor clone 43. We have determined the X-ray structure of the p58 NK-cell inhibitory receptor clone 42 at 1.7-A resolution. The structure has tandem immunoglobulin-like domains positioned at an acute, 60-degree angle. Loops on the outside of the elbow between the domains form a binding site projected away from the NK-cell surface. The topology of the domains and their arrangement relative to each other reveal a relationship to the haematopoietic receptor family, with implications for the signalling mechanism in NK cells."xsd:string |
| http://purl.uniprot.org/citations/9288975 | http://purl.org/dc/terms/identifier | "doi:10.1038/38028"xsd:string |
| http://purl.uniprot.org/citations/9288975 | http://purl.org/dc/terms/identifier | "doi:10.1038/38028"xsd:string |
| http://purl.uniprot.org/citations/9288975 | http://purl.uniprot.org/core/author | "Wiley D.C."xsd:string |
| http://purl.uniprot.org/citations/9288975 | http://purl.uniprot.org/core/author | "Wiley D.C."xsd:string |
| http://purl.uniprot.org/citations/9288975 | http://purl.uniprot.org/core/author | "Winter C.C."xsd:string |
| http://purl.uniprot.org/citations/9288975 | http://purl.uniprot.org/core/author | "Winter C.C."xsd:string |
| http://purl.uniprot.org/citations/9288975 | http://purl.uniprot.org/core/author | "Mosyak L."xsd:string |
| http://purl.uniprot.org/citations/9288975 | http://purl.uniprot.org/core/author | "Mosyak L."xsd:string |
| http://purl.uniprot.org/citations/9288975 | http://purl.uniprot.org/core/author | "Fan Q.R."xsd:string |
| http://purl.uniprot.org/citations/9288975 | http://purl.uniprot.org/core/author | "Fan Q.R."xsd:string |
| http://purl.uniprot.org/citations/9288975 | http://purl.uniprot.org/core/author | "Long E.O."xsd:string |
| http://purl.uniprot.org/citations/9288975 | http://purl.uniprot.org/core/author | "Long E.O."xsd:string |
| http://purl.uniprot.org/citations/9288975 | http://purl.uniprot.org/core/author | "Wagtmann N."xsd:string |
| http://purl.uniprot.org/citations/9288975 | http://purl.uniprot.org/core/author | "Wagtmann N."xsd:string |
| http://purl.uniprot.org/citations/9288975 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9288975 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9288975 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/9288975 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/9288975 | http://purl.uniprot.org/core/pages | "96-100"xsd:string |
| http://purl.uniprot.org/citations/9288975 | http://purl.uniprot.org/core/pages | "96-100"xsd:string |
| http://purl.uniprot.org/citations/9288975 | http://purl.uniprot.org/core/title | "Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors."xsd:string |
| http://purl.uniprot.org/citations/9288975 | http://purl.uniprot.org/core/title | "Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors."xsd:string |