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http://purl.uniprot.org/citations/9299541http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9299541http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9299541http://www.w3.org/2000/01/rdf-schema#comment"We have isolated the chicken homeobox genes LH-2A and LH-2B encoding two related LIM domain-containing homeodomain proteins and examined the expression pattern during chick limb development. LH-2A is most closely related to human and rat LH-2, while LH-2B is less conserved. Although both LH-2A and LH-2B are expressed in the limb mesenchyme throughout stage 16 to stage 32, LH-2A transcripts are detectable in the distal limb bud and LH-2B transcripts are detectable in the anterior limb bud. Signals from the apical ectodermal ridge positively regulate LH-2A expression, since removal of the apical ectoderm resulted in the rapid reduction of LH-2A expression in the distal limb mesenchyme. Ectopic expression of the sonic hedgehog gene in the anterior margin of the limb bud resulted in the rapid reduction of LH-2B expression accompanying respecification of the positional value to the posterior phenotype. These results suggest that LH-2A and LH-2B play important roles in the determination and specification of the proximal-distal and anterior-posterior positional values, respectively."xsd:string
http://purl.uniprot.org/citations/9299541http://purl.org/dc/terms/identifier"doi:10.1006/bbrc.1997.7320"xsd:string
http://purl.uniprot.org/citations/9299541http://purl.org/dc/terms/identifier"doi:10.1006/bbrc.1997.7320"xsd:string
http://purl.uniprot.org/citations/9299541http://purl.uniprot.org/core/author"Ishikawa T."xsd:string
http://purl.uniprot.org/citations/9299541http://purl.uniprot.org/core/author"Ishikawa T."xsd:string
http://purl.uniprot.org/citations/9299541http://purl.uniprot.org/core/author"Wada N."xsd:string
http://purl.uniprot.org/citations/9299541http://purl.uniprot.org/core/author"Wada N."xsd:string
http://purl.uniprot.org/citations/9299541http://purl.uniprot.org/core/author"Noji S."xsd:string
http://purl.uniprot.org/citations/9299541http://purl.uniprot.org/core/author"Noji S."xsd:string
http://purl.uniprot.org/citations/9299541http://purl.uniprot.org/core/author"Kawakami Y."xsd:string
http://purl.uniprot.org/citations/9299541http://purl.uniprot.org/core/author"Kawakami Y."xsd:string
http://purl.uniprot.org/citations/9299541http://purl.uniprot.org/core/author"Nohno T."xsd:string
http://purl.uniprot.org/citations/9299541http://purl.uniprot.org/core/author"Nohno T."xsd:string
http://purl.uniprot.org/citations/9299541http://purl.uniprot.org/core/author"Ohuchi H."xsd:string
http://purl.uniprot.org/citations/9299541http://purl.uniprot.org/core/author"Ohuchi H."xsd:string
http://purl.uniprot.org/citations/9299541http://purl.uniprot.org/core/date"1997"xsd:gYear
http://purl.uniprot.org/citations/9299541http://purl.uniprot.org/core/date"1997"xsd:gYear
http://purl.uniprot.org/citations/9299541http://purl.uniprot.org/core/name"Biochem. Biophys. Res. Commun."xsd:string
http://purl.uniprot.org/citations/9299541http://purl.uniprot.org/core/name"Biochem. Biophys. Res. Commun."xsd:string
http://purl.uniprot.org/citations/9299541http://purl.uniprot.org/core/pages"506-511"xsd:string
http://purl.uniprot.org/citations/9299541http://purl.uniprot.org/core/pages"506-511"xsd:string
http://purl.uniprot.org/citations/9299541http://purl.uniprot.org/core/title"Differential expression of the two closely related LIM-class homeobox genes LH-2A and LH-2B during limb development."xsd:string
http://purl.uniprot.org/citations/9299541http://purl.uniprot.org/core/title"Differential expression of the two closely related LIM-class homeobox genes LH-2A and LH-2B during limb development."xsd:string