| http://purl.uniprot.org/citations/9303303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9303303 | http://www.w3.org/2000/01/rdf-schema#comment | "Synaptotagmins are synaptic vesicle proteins containing two calcium-binding C2 domains which are involved in coupling calcium influx through voltage-gated channels to vesicle fusion and exocytosis of neurotransmitters. The interaction of synaptotagmins with native P/Q-type calcium channels was studied in solubilized synaptosomes from rat cerebellum. Antibodies against synaptotagmins I and II, but not IV co-immunoprecipitated [125I]omega-conotoxin MVIIC-labelled calcium channels. Direct interactions were studied between in vitro-translated [35S]synaptotagmin I and fusion proteins containing cytoplasmic loops of the alpha1A subunit (BI isoform). Gel overlay revealed the association of synaptotagmin I with a single region (residues 780-969) located in the intracellular loop connecting homologous domains II and III. Saturable calcium-independent binding occurred with equilibrium dissociation constants of 70 nM and 340 nM at 4 degrees C and pH 7.4, and association was blocked by addition of excess recombinant synaptotagmin I. Direct synaptotagmin binding to the pore-forming subunit of the P/Q-type channel may optimally locate the calcium-binding sites that initiate exocytosis within a zone of voltage-gated calcium entry."xsd:string |
| http://purl.uniprot.org/citations/9303303 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/16.15.4591"xsd:string |
| http://purl.uniprot.org/citations/9303303 | http://purl.uniprot.org/core/author | "De Waard M."xsd:string |
| http://purl.uniprot.org/citations/9303303 | http://purl.uniprot.org/core/author | "Kataoka M."xsd:string |
| http://purl.uniprot.org/citations/9303303 | http://purl.uniprot.org/core/author | "Takahashi M."xsd:string |
| http://purl.uniprot.org/citations/9303303 | http://purl.uniprot.org/core/author | "Raymond C."xsd:string |
| http://purl.uniprot.org/citations/9303303 | http://purl.uniprot.org/core/author | "Walker D."xsd:string |
| http://purl.uniprot.org/citations/9303303 | http://purl.uniprot.org/core/author | "Seagar M.J."xsd:string |
| http://purl.uniprot.org/citations/9303303 | http://purl.uniprot.org/core/author | "Berton F."xsd:string |
| http://purl.uniprot.org/citations/9303303 | http://purl.uniprot.org/core/author | "Charvin N."xsd:string |
| http://purl.uniprot.org/citations/9303303 | http://purl.uniprot.org/core/author | "L'eveque C."xsd:string |
| http://purl.uniprot.org/citations/9303303 | http://purl.uniprot.org/core/author | "Shoji-Kasai Y."xsd:string |
| http://purl.uniprot.org/citations/9303303 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9303303 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/9303303 | http://purl.uniprot.org/core/pages | "4591-4596"xsd:string |
| http://purl.uniprot.org/citations/9303303 | http://purl.uniprot.org/core/title | "Direct interaction of the calcium sensor protein synaptotagmin I with a cytoplasmic domain of the alpha1A subunit of the P/Q-type calcium channel."xsd:string |
| http://purl.uniprot.org/citations/9303303 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/9303303 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9303303 |
| http://purl.uniprot.org/citations/9303303 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9303303 |
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| http://purl.uniprot.org/uniprot/#_P54282-mappedCitation-9303303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9303303 |
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| http://purl.uniprot.org/uniprot/#_A0A8L2R1E5-mappedCitation-9303303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9303303 |
| http://purl.uniprot.org/uniprot/#_A0A8I5Y6Y2-mappedCitation-9303303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9303303 |