| http://purl.uniprot.org/citations/9305650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9305650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9305650 | http://www.w3.org/2000/01/rdf-schema#comment | "Nup145p is an essential yeast nucleoporin involved in nuclear export of polyadenylated RNAs. We demonstrate here that Nup145p is cleaved in vivo to yield two functionally distinct domains: a carboxy-terminal domain (C-Nup145p) which is located at the nuclear pore complex (NPC) and assembles into the Nup84p complex, and a GLFG-containing amino-terminal domain (N-Nup145p) which is not part of this complex. Whereas the essential C-Nup145p accomplishes the functions required for efficient mRNA export and normal NPC distribution, N-Nup145p, which is homologous to the GLFG-containing nucleoporins Nup100p and Nup116p, is not necessary for cell growth. However, the N-Nup145p becomes essential in a nup188 mutant background. Strikingly, generation of a free N-domain is a prerequisite for complementation of this peculiar synthetic lethal mutant. These data suggest that N- and C-domains of Nup145p perform independent functions, and that the in vivo cleavage observed is of functional importance."xsd:string |
| http://purl.uniprot.org/citations/9305650 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/16.16.5086"xsd:string |
| http://purl.uniprot.org/citations/9305650 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/16.16.5086"xsd:string |
| http://purl.uniprot.org/citations/9305650 | http://purl.uniprot.org/core/author | "Mann M."xsd:string |
| http://purl.uniprot.org/citations/9305650 | http://purl.uniprot.org/core/author | "Mann M."xsd:string |
| http://purl.uniprot.org/citations/9305650 | http://purl.uniprot.org/core/author | "Dujon B."xsd:string |
| http://purl.uniprot.org/citations/9305650 | http://purl.uniprot.org/core/author | "Dujon B."xsd:string |
| http://purl.uniprot.org/citations/9305650 | http://purl.uniprot.org/core/author | "Fabre E."xsd:string |
| http://purl.uniprot.org/citations/9305650 | http://purl.uniprot.org/core/author | "Fabre E."xsd:string |
| http://purl.uniprot.org/citations/9305650 | http://purl.uniprot.org/core/author | "Hurt E.C."xsd:string |
| http://purl.uniprot.org/citations/9305650 | http://purl.uniprot.org/core/author | "Hurt E.C."xsd:string |
| http://purl.uniprot.org/citations/9305650 | http://purl.uniprot.org/core/author | "Siniossoglou S."xsd:string |
| http://purl.uniprot.org/citations/9305650 | http://purl.uniprot.org/core/author | "Siniossoglou S."xsd:string |
| http://purl.uniprot.org/citations/9305650 | http://purl.uniprot.org/core/author | "Teixeira M.T."xsd:string |
| http://purl.uniprot.org/citations/9305650 | http://purl.uniprot.org/core/author | "Teixeira M.T."xsd:string |
| http://purl.uniprot.org/citations/9305650 | http://purl.uniprot.org/core/author | "Benichou J.C."xsd:string |
| http://purl.uniprot.org/citations/9305650 | http://purl.uniprot.org/core/author | "Benichou J.C."xsd:string |
| http://purl.uniprot.org/citations/9305650 | http://purl.uniprot.org/core/author | "Podtelejnikov S."xsd:string |
| http://purl.uniprot.org/citations/9305650 | http://purl.uniprot.org/core/author | "Podtelejnikov S."xsd:string |
| http://purl.uniprot.org/citations/9305650 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9305650 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9305650 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/9305650 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |