| http://purl.uniprot.org/citations/9305758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9305758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9305758 | http://www.w3.org/2000/01/rdf-schema#comment | "The cloning of signal transducing molecules capable of activating the human FOS proto-oncogene promoter was achieved by co-transfecting a modified human FOS promoter-driven polyomavirus large T antigen gene (P(f)LAG-8) with a human brain cDNA library, incorporated into a replication-competent mammalian retroviral expression vector whose replication occurs in the presence of T antigen. In murine cells, transcriptional activation of the P(f)LAG-8 promoter by a biologically active, cDNA-encoded signalling molecule resulted in plasmid replication. Replicated plasmids, following selective cleavage of unreplicated plasmids by Dpn1, were recovered by transformation into competent bacteria. Successive P(f)LAG-8/cDNA library co-transfections, using library plasmids resulting from prior transfections, ultimately resulted in the identification of individual plasmids capable of transcriptionally activating the FOS promoter. DNA sequencing revealed the first plasmid, denoted CROC-1, to contain a 1.8-kb cDNA encoding a 16.5-kDa nuclear protein possessing a bipartite structure comprised an amino-terminal acidic domain and a carboxy-terminal basic domain, and displaying partial homology to the HMG domain of the TAF(II)250 transcription cofactor. Co-transfection of CROC-1 with various FOS/CAT reporter genes revealed that the human FOS promoter region spanning -56 to - 105, encompassing two identical 8-bp DR enhancer sequences, was necessary for CROC-1-mediated transcriptional activation. Results suggest that CROC-1 participates in intracellular signalling pathways involved in induction of the human FOS promoter."xsd:string |
| http://purl.uniprot.org/citations/9305758 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0378-1119(97)00097-8"xsd:string |
| http://purl.uniprot.org/citations/9305758 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0378-1119(97)00097-8"xsd:string |
| http://purl.uniprot.org/citations/9305758 | http://purl.uniprot.org/core/author | "Lin S.L."xsd:string |
| http://purl.uniprot.org/citations/9305758 | http://purl.uniprot.org/core/author | "Lin S.L."xsd:string |
| http://purl.uniprot.org/citations/9305758 | http://purl.uniprot.org/core/author | "Rothofsky M.L."xsd:string |
| http://purl.uniprot.org/citations/9305758 | http://purl.uniprot.org/core/author | "Rothofsky M.L."xsd:string |
| http://purl.uniprot.org/citations/9305758 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9305758 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9305758 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/9305758 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/9305758 | http://purl.uniprot.org/core/pages | "141-149"xsd:string |
| http://purl.uniprot.org/citations/9305758 | http://purl.uniprot.org/core/pages | "141-149"xsd:string |
| http://purl.uniprot.org/citations/9305758 | http://purl.uniprot.org/core/title | "CROC-1 encodes a protein which mediates transcriptional activation of the human FOS promoter."xsd:string |
| http://purl.uniprot.org/citations/9305758 | http://purl.uniprot.org/core/title | "CROC-1 encodes a protein which mediates transcriptional activation of the human FOS promoter."xsd:string |
| http://purl.uniprot.org/citations/9305758 | http://purl.uniprot.org/core/volume | "195"xsd:string |
| http://purl.uniprot.org/citations/9305758 | http://purl.uniprot.org/core/volume | "195"xsd:string |
| http://purl.uniprot.org/citations/9305758 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9305758 |
| http://purl.uniprot.org/citations/9305758 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9305758 |
| http://purl.uniprot.org/citations/9305758 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9305758 |
| http://purl.uniprot.org/citations/9305758 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9305758 |
| http://purl.uniprot.org/uniprot/Q13404 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/9305758 |
| http://purl.uniprot.org/uniprot/#_kb.Q13404_up.isolatedFrom_tissue.95 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/9305758 |