| http://purl.uniprot.org/citations/9305844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9305844 | http://www.w3.org/2000/01/rdf-schema#comment | "A variety of extracellular signals are transduced across the cell membrane by the enzyme phosphoinositide-specific phospholipase C-beta (PLC-beta) coupled with guanine-nucleotide-binding G proteins. There are four isoenzymes of PLC-beta, beta1-beta4, but their functions in vivo are not known. Here we investigate the role of PLC-beta1 and PLC-beta4 in the brain by generating null mutations in mice: we found that PLCbeta1-/-mice developed epilepsy and PLCbeta4-/-mice showed ataxia. We determined the molecular basis of these phenotypes and show that PLC-beta1 is involved in signal transduction in the cerebral cortex and hippocampus by coupling predominantly to the muscarinic acetylcholine receptor, whereas PLC-beta4 works through the metabotropic glutamate receptor in the cerebellum, illustrating how PLC-beta isoenzymes are used to generate different functions in the brain."xsd:string |
| http://purl.uniprot.org/citations/9305844 | http://purl.org/dc/terms/identifier | "doi:10.1038/38508"xsd:string |
| http://purl.uniprot.org/citations/9305844 | http://purl.uniprot.org/core/author | "Kim Y.H."xsd:string |
| http://purl.uniprot.org/citations/9305844 | http://purl.uniprot.org/core/author | "Lee S.B."xsd:string |
| http://purl.uniprot.org/citations/9305844 | http://purl.uniprot.org/core/author | "Kim D."xsd:string |
| http://purl.uniprot.org/citations/9305844 | http://purl.uniprot.org/core/author | "Shin H.S."xsd:string |
| http://purl.uniprot.org/citations/9305844 | http://purl.uniprot.org/core/author | "Ryu S.H."xsd:string |
| http://purl.uniprot.org/citations/9305844 | http://purl.uniprot.org/core/author | "Suh P.G."xsd:string |
| http://purl.uniprot.org/citations/9305844 | http://purl.uniprot.org/core/author | "Min D.S."xsd:string |
| http://purl.uniprot.org/citations/9305844 | http://purl.uniprot.org/core/author | "Jun K.S."xsd:string |
| http://purl.uniprot.org/citations/9305844 | http://purl.uniprot.org/core/author | "Kang N.G."xsd:string |
| http://purl.uniprot.org/citations/9305844 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9305844 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/9305844 | http://purl.uniprot.org/core/pages | "290-293"xsd:string |
| http://purl.uniprot.org/citations/9305844 | http://purl.uniprot.org/core/title | "Phospholipase C isozymes selectively couple to specific neurotransmitter receptors."xsd:string |
| http://purl.uniprot.org/citations/9305844 | http://purl.uniprot.org/core/volume | "389"xsd:string |
| http://purl.uniprot.org/citations/9305844 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9305844 |
| http://purl.uniprot.org/citations/9305844 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9305844 |
| http://purl.uniprot.org/uniprot/Q9Z1B3#attribution-C0EE64388A1D5961391A7F51D98EA935 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9305844 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YUY5-mappedCitation-9305844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9305844 |
| http://purl.uniprot.org/uniprot/#_A0A494B9C1-mappedCitation-9305844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9305844 |
| http://purl.uniprot.org/uniprot/#_A0A494BAY4-mappedCitation-9305844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9305844 |
| http://purl.uniprot.org/uniprot/#_A2AT91-mappedCitation-9305844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9305844 |
| http://purl.uniprot.org/uniprot/#_A2AT93-mappedCitation-9305844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9305844 |