| http://purl.uniprot.org/citations/9305846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9305846 | http://www.w3.org/2000/01/rdf-schema#comment | "Heterotrimeric guanine-nucleotide-binding regulatory proteins (G proteins) transduce signals from a wide variety of cell-surface receptors to generate physiological responses. Protein-tyrosine kinases are another group of critical cellular signal transducers and their malfunction often leads to cancer. Although activation of G-protein-coupled receptors can elicit rapid stimulation of cellular protein-tyrosine phosphorylation, the mechanism used by G proteins to activate protein-tyrosine kinases is unclear. Here we show that the purified alpha-subunit of the G(q) class of G proteins (G[alpha]q) directly stimulates the activity of a purified non-receptor kinase, Bruton's tyrosine kinase (Btk), whereas purified alpha-subunits from G(il), G(O) or G(z) proteins do not. G(alpha)q can also activate Btk in vivo. Furthermore, in Btk-deficient cells, stimulation of another kinase, a p38 MAP kinase, by Gq-coupled receptors is blocked. Our results demonstrate that certain protein-tyrosine kinases can be direct effectors of G proteins."xsd:string |
| http://purl.uniprot.org/citations/9305846 | http://purl.org/dc/terms/identifier | "doi:10.1038/38520"xsd:string |
| http://purl.uniprot.org/citations/9305846 | http://purl.uniprot.org/core/author | "Ma W."xsd:string |
| http://purl.uniprot.org/citations/9305846 | http://purl.uniprot.org/core/author | "Huang X.Y."xsd:string |
| http://purl.uniprot.org/citations/9305846 | http://purl.uniprot.org/core/author | "Kozasa T."xsd:string |
| http://purl.uniprot.org/citations/9305846 | http://purl.uniprot.org/core/author | "Bence K."xsd:string |
| http://purl.uniprot.org/citations/9305846 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9305846 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/9305846 | http://purl.uniprot.org/core/pages | "296-299"xsd:string |
| http://purl.uniprot.org/citations/9305846 | http://purl.uniprot.org/core/title | "Direct stimulation of Bruton's tyrosine kinase by G(q)-protein alpha-subunit."xsd:string |
| http://purl.uniprot.org/citations/9305846 | http://purl.uniprot.org/core/volume | "389"xsd:string |
| http://purl.uniprot.org/citations/9305846 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9305846 |
| http://purl.uniprot.org/citations/9305846 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9305846 |
| http://purl.uniprot.org/uniprot/#_P50148-mappedCitation-9305846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9305846 |
| http://purl.uniprot.org/uniprot/#_Q06187-mappedCitation-9305846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9305846 |
| http://purl.uniprot.org/uniprot/#_O95837-mappedCitation-9305846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9305846 |
| http://purl.uniprot.org/uniprot/#_P29992-mappedCitation-9305846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9305846 |
| http://purl.uniprot.org/uniprot/#_P30679-mappedCitation-9305846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9305846 |
| http://purl.uniprot.org/uniprot/P50148 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9305846 |
| http://purl.uniprot.org/uniprot/O95837 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9305846 |
| http://purl.uniprot.org/uniprot/Q06187 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9305846 |
| http://purl.uniprot.org/uniprot/P29992 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9305846 |
| http://purl.uniprot.org/uniprot/P30679 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9305846 |