| http://purl.uniprot.org/citations/9310332 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9310332 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in the human fibroblast growth factor receptor type 2 (FGFR2) gene cause craniosynostosis, particularly affecting the coronal suture. We show here that, in the fetal mouse skull vault, Fgfr2 transcripts are most abundant at the periphery of the membrane bones; they are mutually exclusive with those of osteopontin (an early marker of osteogenic differentiation) but coincide with sites of rapid cell proliferation. Fibroblast growth factor type 2 (FGF2) protein, which has a high affinity for the FGFR2 splice variant associated with craniosynostosis, is locally abundant; immunohistochemical detection showed it to be present at low levels in Fgfr2 expression domains and at high levels in differentiated areas. Implantation of FGF2-soaked beads onto the fetal coronal suture by ex utero surgery resulted in ectopic osteopontin expression, encircled by Fgfr2 expression, after 48 hours. We suggest that increased FGF/FGFR signalling in the developing skull, whether due to FGFR2 mutation or to ectopic FGF2, shifts the cell proliferation/differentiation balance towards differentiation by enhancing the normal paracrine down-regulation of Fgfr2."xsd:string |
| http://purl.uniprot.org/citations/9310332 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.124.17.3375"xsd:string |
| http://purl.uniprot.org/citations/9310332 | http://purl.uniprot.org/core/author | "Heath J.K."xsd:string |
| http://purl.uniprot.org/citations/9310332 | http://purl.uniprot.org/core/author | "Eto K."xsd:string |
| http://purl.uniprot.org/citations/9310332 | http://purl.uniprot.org/core/author | "Morriss-Kay G.M."xsd:string |
| http://purl.uniprot.org/citations/9310332 | http://purl.uniprot.org/core/author | "Ishimaru T."xsd:string |
| http://purl.uniprot.org/citations/9310332 | http://purl.uniprot.org/core/author | "Wilkie A.O."xsd:string |
| http://purl.uniprot.org/citations/9310332 | http://purl.uniprot.org/core/author | "Iseki S."xsd:string |
| http://purl.uniprot.org/citations/9310332 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9310332 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/9310332 | http://purl.uniprot.org/core/pages | "3375-3384"xsd:string |
| http://purl.uniprot.org/citations/9310332 | http://purl.uniprot.org/core/title | "Fgfr2 and osteopontin domains in the developing skull vault are mutually exclusive and can be altered by locally applied FGF2."xsd:string |
| http://purl.uniprot.org/citations/9310332 | http://purl.uniprot.org/core/volume | "124"xsd:string |
| http://purl.uniprot.org/citations/9310332 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9310332 |
| http://purl.uniprot.org/citations/9310332 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9310332 |
| http://purl.uniprot.org/uniprot/#_D3Z116-mappedCitation-9310332 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9310332 |
| http://purl.uniprot.org/uniprot/#_D3Z5M8-mappedCitation-9310332 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9310332 |
| http://purl.uniprot.org/uniprot/#_E9Q700-mappedCitation-9310332 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9310332 |
| http://purl.uniprot.org/uniprot/#_E9Q708-mappedCitation-9310332 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9310332 |
| http://purl.uniprot.org/uniprot/#_E9Q7C7-mappedCitation-9310332 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9310332 |
| http://purl.uniprot.org/uniprot/#_E9Q7E6-mappedCitation-9310332 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9310332 |
| http://purl.uniprot.org/uniprot/#_E9Q7E8-mappedCitation-9310332 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9310332 |
| http://purl.uniprot.org/uniprot/#_E9Q7T0-mappedCitation-9310332 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9310332 |
| http://purl.uniprot.org/uniprot/#_A1YYM3-mappedCitation-9310332 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9310332 |