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http://purl.uniprot.org/citations/9311920http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9311920http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9311920http://www.w3.org/2000/01/rdf-schema#comment"Expression of Agouti protein is normally limited to the skin where it affects pigmentation, but ubiquitous expression causes obesity. An expressed sequence tag was identified that encodes Agouti-related protein, whose RNA is normally expressed in the hypothalamus and whose levels were increased eightfold in ob/ob mice. Recombinant Agouti-related protein was a potent, selective antagonist of Mc3r and Mc4r, melanocortin receptor subtypes implicated in weight regulation. Ubiquitous expression of human AGRP complementary DNA in transgenic mice caused obesity without altering pigmentation. Thus, Agouti-related protein is a neuropeptide implicated in the normal control of body weight downstream of leptin signaling."xsd:string
http://purl.uniprot.org/citations/9311920http://purl.org/dc/terms/identifier"doi:10.1126/science.278.5335.135"xsd:string
http://purl.uniprot.org/citations/9311920http://purl.org/dc/terms/identifier"doi:10.1126/science.278.5335.135"xsd:string
http://purl.uniprot.org/citations/9311920http://purl.uniprot.org/core/author"Chen Y."xsd:string
http://purl.uniprot.org/citations/9311920http://purl.uniprot.org/core/author"Chen Y."xsd:string
http://purl.uniprot.org/citations/9311920http://purl.uniprot.org/core/author"Kerns J.A."xsd:string
http://purl.uniprot.org/citations/9311920http://purl.uniprot.org/core/author"Kerns J.A."xsd:string
http://purl.uniprot.org/citations/9311920http://purl.uniprot.org/core/author"Gantz I."xsd:string
http://purl.uniprot.org/citations/9311920http://purl.uniprot.org/core/author"Gantz I."xsd:string
http://purl.uniprot.org/citations/9311920http://purl.uniprot.org/core/author"Barsh G.S."xsd:string
http://purl.uniprot.org/citations/9311920http://purl.uniprot.org/core/author"Barsh G.S."xsd:string
http://purl.uniprot.org/citations/9311920http://purl.uniprot.org/core/author"Ollmann M.M."xsd:string
http://purl.uniprot.org/citations/9311920http://purl.uniprot.org/core/author"Ollmann M.M."xsd:string
http://purl.uniprot.org/citations/9311920http://purl.uniprot.org/core/author"Wilson B.D."xsd:string
http://purl.uniprot.org/citations/9311920http://purl.uniprot.org/core/author"Wilson B.D."xsd:string
http://purl.uniprot.org/citations/9311920http://purl.uniprot.org/core/author"Yang Y.K."xsd:string
http://purl.uniprot.org/citations/9311920http://purl.uniprot.org/core/author"Yang Y.K."xsd:string
http://purl.uniprot.org/citations/9311920http://purl.uniprot.org/core/date"1997"xsd:gYear
http://purl.uniprot.org/citations/9311920http://purl.uniprot.org/core/date"1997"xsd:gYear
http://purl.uniprot.org/citations/9311920http://purl.uniprot.org/core/name"Science"xsd:string
http://purl.uniprot.org/citations/9311920http://purl.uniprot.org/core/name"Science"xsd:string
http://purl.uniprot.org/citations/9311920http://purl.uniprot.org/core/pages"135-138"xsd:string
http://purl.uniprot.org/citations/9311920http://purl.uniprot.org/core/pages"135-138"xsd:string