| http://purl.uniprot.org/citations/9311991 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9311991 | http://www.w3.org/2000/01/rdf-schema#comment | "The expression of the high mobility group I (HMGI)-C chromatin component was shown previously to be essential for the establishment of the neoplastic phenotype in retrovirally transformed thyroid cell lines. To identify possible targets of the HMGI-C gene product, we have analyzed the AP-1 complex in normal, fully transformed and antisense HMGI-C-expressing rat thyroid cells. We show that neoplastic transformation is associated with a drastic increase in AP-1 activity, which reflects multiple compositional changes. The strongest effect is represented by the dramatic junB and fra-1 gene induction, which is prevented in cell lines expressing the antisense HMGI-C. These results indicate that the HMGI-C gene product is essential for the junB and fra-1 transcriptional induction associated with neoplastic transformation. The inhibition of Fra-1 protein synthesis by stable transfection with a fra-1 antisense RNA vector significantly reduces the malignant phenotype of the transformed thyroid cells, indicating a pivotal role for the fra-1 gene product in the process of cellular transformation."xsd:string |
| http://purl.uniprot.org/citations/9311991 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/16.17.5310"xsd:string |
| http://purl.uniprot.org/citations/9311991 | http://purl.uniprot.org/core/author | "Santoro M."xsd:string |
| http://purl.uniprot.org/citations/9311991 | http://purl.uniprot.org/core/author | "Fedele M."xsd:string |
| http://purl.uniprot.org/citations/9311991 | http://purl.uniprot.org/core/author | "Fusco A."xsd:string |
| http://purl.uniprot.org/citations/9311991 | http://purl.uniprot.org/core/author | "Viglietto G."xsd:string |
| http://purl.uniprot.org/citations/9311991 | http://purl.uniprot.org/core/author | "Verde P."xsd:string |
| http://purl.uniprot.org/citations/9311991 | http://purl.uniprot.org/core/author | "Vallone D."xsd:string |
| http://purl.uniprot.org/citations/9311991 | http://purl.uniprot.org/core/author | "Pierantoni G.M."xsd:string |
| http://purl.uniprot.org/citations/9311991 | http://purl.uniprot.org/core/author | "Battista S."xsd:string |
| http://purl.uniprot.org/citations/9311991 | http://purl.uniprot.org/core/author | "Casalino L."xsd:string |
| http://purl.uniprot.org/citations/9311991 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9311991 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/9311991 | http://purl.uniprot.org/core/pages | "5310-5321"xsd:string |
| http://purl.uniprot.org/citations/9311991 | http://purl.uniprot.org/core/title | "Neoplastic transformation of rat thyroid cells requires the junB and fra-1 gene induction which is dependent on the HMGI-C gene product."xsd:string |
| http://purl.uniprot.org/citations/9311991 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/9311991 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9311991 |
| http://purl.uniprot.org/citations/9311991 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9311991 |
| http://purl.uniprot.org/uniprot/#_A0A8I6A172-mappedCitation-9311991 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9311991 |
| http://purl.uniprot.org/uniprot/#_A0A8I6GCP7-mappedCitation-9311991 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9311991 |
| http://purl.uniprot.org/uniprot/#_O88791-mappedCitation-9311991 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9311991 |
| http://purl.uniprot.org/uniprot/O88791 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9311991 |
| http://purl.uniprot.org/uniprot/A0A8I6GCP7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9311991 |
| http://purl.uniprot.org/uniprot/A0A8I6A172 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9311991 |