| http://purl.uniprot.org/citations/9312079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9312079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9312079 | http://www.w3.org/2000/01/rdf-schema#comment | "Cdc42 plays an important role in intracellular signaling pathways that influence cell morphology and motility and stimulate DNA synthesis. In attempts to determine whether nonreceptor tyrosine kinases play a fundamental role in Cdc42 signaling, we have cloned and biochemically characterized a new Cdc42-associated tyrosine kinase (ACK) from bovine brain. This tyrosine kinase, named ACK-2, has a calculated molecular mass of 83 kDa and shares a number of primary structural domains with the 120-kDa ACK (ACK-1). The main differences between the primary structures of ACK-2 and ACK-1 occur in the amino- and carboxyl-terminal regions. Like ACK-1, ACK-2 binds exclusively to activated (GTP-bound) Cdc42 and does not bind to its closest homologs, e.g. activated Rac. ACK-2 could not be activated by addition of glutathione S-transferase (GST)-Cdc42(Q61L), a GTPase-defective mutant, or by GTPgammaS-loaded GST-Cdc42 in in vitro kinase assays. However, ACK-2 was activated when cotransfected with wild type Cdc42 or Cdc42(Q61L) and stably associated with Cdc42(Q61L) in vivo, indicating that ACK-2 interacts with active Cdc42 in cells. Furthermore, the tyrosine kinase activity of ACK-2 was stimulated both by epidermal growth factor and bradykinin, suggesting that ACK-2 may play a role in the signaling actions of both receptor tyrosine kinases or heterotrimeric G-protein-coupled receptors."xsd:string |
| http://purl.uniprot.org/citations/9312079 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.272.40.24819"xsd:string |
| http://purl.uniprot.org/citations/9312079 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.272.40.24819"xsd:string |
| http://purl.uniprot.org/citations/9312079 | http://purl.uniprot.org/core/author | "Cerione R.A."xsd:string |
| http://purl.uniprot.org/citations/9312079 | http://purl.uniprot.org/core/author | "Cerione R.A."xsd:string |
| http://purl.uniprot.org/citations/9312079 | http://purl.uniprot.org/core/author | "Yang W."xsd:string |
| http://purl.uniprot.org/citations/9312079 | http://purl.uniprot.org/core/author | "Yang W."xsd:string |
| http://purl.uniprot.org/citations/9312079 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9312079 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9312079 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9312079 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9312079 | http://purl.uniprot.org/core/pages | "24819-24824"xsd:string |
| http://purl.uniprot.org/citations/9312079 | http://purl.uniprot.org/core/pages | "24819-24824"xsd:string |
| http://purl.uniprot.org/citations/9312079 | http://purl.uniprot.org/core/title | "Cloning and characterization of a novel Cdc42-associated tyrosine kinase, ACK-2, from bovine brain."xsd:string |
| http://purl.uniprot.org/citations/9312079 | http://purl.uniprot.org/core/title | "Cloning and characterization of a novel Cdc42-associated tyrosine kinase, ACK-2, from bovine brain."xsd:string |
| http://purl.uniprot.org/citations/9312079 | http://purl.uniprot.org/core/volume | "272"xsd:string |
| http://purl.uniprot.org/citations/9312079 | http://purl.uniprot.org/core/volume | "272"xsd:string |
| http://purl.uniprot.org/citations/9312079 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9312079 |
| http://purl.uniprot.org/citations/9312079 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9312079 |
| http://purl.uniprot.org/citations/9312079 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9312079 |
| http://purl.uniprot.org/citations/9312079 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9312079 |
| http://purl.uniprot.org/uniprot/Q17R13 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/9312079 |
| http://purl.uniprot.org/embl-cds/AAC05310.1 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/9312079 |