| http://purl.uniprot.org/citations/9314552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9314552 | http://www.w3.org/2000/01/rdf-schema#comment | "Receptors on macrophages for the Fc region of IgG (FcgammaR) mediate a number of responses important for host immunity. Signaling events necessary for these responses are likely initiated by the activation of Src-family and Syk-family tyrosine kinases after FcgammaR cross-linking. Macrophages derived from Syk-deficient (Syk-) mice were defective in phagocytosis of particles bound by FcgammaRs, as well as in many FcgammaR-induced signaling events, including tyrosine phosphorylation of a number of cellular substrates and activation of MAP kinases. In contrast, Syk-macrophages exhibited normal responses to another potent macrophage stimulus, lipopolysaccharide. Phagocytosis of latex beads and Escherichia coli bacteria was also not affected. Syk-macrophages exhibited formation of polymerized actin structures opposing particles bound to the cells by FcgammaRs (actin cups), but failed to proceed to internalization. Interestingly, inhibitors of phosphatidylinositol 3-kinase also blocked FcgammaR-mediated phagocytosis at this stage. Thus, PI 3-kinase may participate in a Syk-dependent signaling pathway critical for FcgammaR-mediated phagocytosis. Macrophages derived from mice deficient for the three members of the Src-family of kinases expressed in these cells, Hck, Fgr, and Lyn, exhibited poor Syk activation upon FcgammaR engagement, accompanied by a delay in FcgammaR-mediated phagocytosis. These observations demonstrate that Syk is critical for FcgammaR-mediated phagocytosis, as well as for signal transduction in macrophages. Additionally, our findings provide evidence to support a model of sequential tyrosine kinase activation by FcgammaR's analogous to models of signaling by the B and T cell antigen receptors."xsd:string |
| http://purl.uniprot.org/citations/9314552 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.186.7.1027"xsd:string |
| http://purl.uniprot.org/citations/9314552 | http://purl.uniprot.org/core/author | "Turner M."xsd:string |
| http://purl.uniprot.org/citations/9314552 | http://purl.uniprot.org/core/author | "Meng F."xsd:string |
| http://purl.uniprot.org/citations/9314552 | http://purl.uniprot.org/core/author | "Tybulewicz V.L."xsd:string |
| http://purl.uniprot.org/citations/9314552 | http://purl.uniprot.org/core/author | "DeFranco A.L."xsd:string |
| http://purl.uniprot.org/citations/9314552 | http://purl.uniprot.org/core/author | "Costello P.S."xsd:string |
| http://purl.uniprot.org/citations/9314552 | http://purl.uniprot.org/core/author | "Lowell C."xsd:string |
| http://purl.uniprot.org/citations/9314552 | http://purl.uniprot.org/core/author | "Crowley M.T."xsd:string |
| http://purl.uniprot.org/citations/9314552 | http://purl.uniprot.org/core/author | "Fitzer-Attas C.J."xsd:string |
| http://purl.uniprot.org/citations/9314552 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9314552 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/9314552 | http://purl.uniprot.org/core/pages | "1027-1039"xsd:string |
| http://purl.uniprot.org/citations/9314552 | http://purl.uniprot.org/core/title | "A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages."xsd:string |
| http://purl.uniprot.org/citations/9314552 | http://purl.uniprot.org/core/volume | "186"xsd:string |
| http://purl.uniprot.org/citations/9314552 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9314552 |
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