| http://purl.uniprot.org/citations/9323135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9323135 | http://www.w3.org/2000/01/rdf-schema#comment | "Gene targeting experiments have demonstrated that the expression of immunoglobulin heavy chain in the pre-B cell receptor (pBCR) and of heavy and light chains in the B cell antigen receptor (BCR) marks checkpoints in early B cell development that the cells have to pass to survive. To investigate whether the persistence of mature B cells in the peripheral immune system also depends on BCR expression, we have generated a transgenic mouse in which the BCR can be inducibly ablated through V region gene deletion. Ablation leads to rapid death of mature B lymphocytes, which is preceded by down-regulation of MHC antigens and up-regulation of CD95 (Fas) and can be delayed by constitutive bcl-2 expression."xsd:string |
| http://purl.uniprot.org/citations/9323135 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)80373-6"xsd:string |
| http://purl.uniprot.org/citations/9323135 | http://purl.uniprot.org/core/author | "Kuhn R."xsd:string |
| http://purl.uniprot.org/citations/9323135 | http://purl.uniprot.org/core/author | "Rajewsky K."xsd:string |
| http://purl.uniprot.org/citations/9323135 | http://purl.uniprot.org/core/author | "Lam K.P."xsd:string |
| http://purl.uniprot.org/citations/9323135 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9323135 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/9323135 | http://purl.uniprot.org/core/pages | "1073-1083"xsd:string |
| http://purl.uniprot.org/citations/9323135 | http://purl.uniprot.org/core/title | "In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death."xsd:string |
| http://purl.uniprot.org/citations/9323135 | http://purl.uniprot.org/core/volume | "90"xsd:string |
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