| http://purl.uniprot.org/citations/9323142 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9323142 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9323142 | http://www.w3.org/2000/01/rdf-schema#comment | "The small GTPase Rab5 plays an essential role in endocytic traffic. Rab GDP dissociation inhibitor delivers Rab5 to the membrane, where a nucleotide exchange activity allows recruitment of an effector protein, Rabaptin-5. Here we uncovered a novel 60 kDa Rab5-binding protein, Rabex-5. Rabex-5 forms a tight physical complex with Rabaptin-5, and this complex is essential for endocytic membrane fusion. Sequencing of mammalian Rabex-5 by nanoelectrospray mass spectrometry and cloning revealed striking homology to Vps9p, a yeast protein implicated in endocytic traffic. Rabex-5 displays GDP/GTP exchange activity on Rab5 upon delivery of the GTPase to the membrane. This demonstrates that a soluble exchange factor coupled to a Rab effector translocates from cytosol to the membrane, where the complex stabilizes the GTPase in the active state."xsd:string |
| http://purl.uniprot.org/citations/9323142 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)80380-3"xsd:string |
| http://purl.uniprot.org/citations/9323142 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)80380-3"xsd:string |
| http://purl.uniprot.org/citations/9323142 | http://purl.uniprot.org/core/author | "Horiuchi H."xsd:string |
| http://purl.uniprot.org/citations/9323142 | http://purl.uniprot.org/core/author | "Horiuchi H."xsd:string |
| http://purl.uniprot.org/citations/9323142 | http://purl.uniprot.org/core/author | "Mann M."xsd:string |
| http://purl.uniprot.org/citations/9323142 | http://purl.uniprot.org/core/author | "Mann M."xsd:string |
| http://purl.uniprot.org/citations/9323142 | http://purl.uniprot.org/core/author | "Wilm M."xsd:string |
| http://purl.uniprot.org/citations/9323142 | http://purl.uniprot.org/core/author | "Wilm M."xsd:string |
| http://purl.uniprot.org/citations/9323142 | http://purl.uniprot.org/core/author | "Lippe R."xsd:string |
| http://purl.uniprot.org/citations/9323142 | http://purl.uniprot.org/core/author | "Lippe R."xsd:string |
| http://purl.uniprot.org/citations/9323142 | http://purl.uniprot.org/core/author | "Rybin V."xsd:string |
| http://purl.uniprot.org/citations/9323142 | http://purl.uniprot.org/core/author | "Rybin V."xsd:string |
| http://purl.uniprot.org/citations/9323142 | http://purl.uniprot.org/core/author | "McBride H.M."xsd:string |
| http://purl.uniprot.org/citations/9323142 | http://purl.uniprot.org/core/author | "McBride H.M."xsd:string |
| http://purl.uniprot.org/citations/9323142 | http://purl.uniprot.org/core/author | "Stenmark H."xsd:string |
| http://purl.uniprot.org/citations/9323142 | http://purl.uniprot.org/core/author | "Stenmark H."xsd:string |
| http://purl.uniprot.org/citations/9323142 | http://purl.uniprot.org/core/author | "Zerial M."xsd:string |
| http://purl.uniprot.org/citations/9323142 | http://purl.uniprot.org/core/author | "Zerial M."xsd:string |
| http://purl.uniprot.org/citations/9323142 | http://purl.uniprot.org/core/author | "Ashman K."xsd:string |
| http://purl.uniprot.org/citations/9323142 | http://purl.uniprot.org/core/author | "Ashman K."xsd:string |
| http://purl.uniprot.org/citations/9323142 | http://purl.uniprot.org/core/author | "Woodman P."xsd:string |
| http://purl.uniprot.org/citations/9323142 | http://purl.uniprot.org/core/author | "Woodman P."xsd:string |