| http://purl.uniprot.org/citations/9325050 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9325050 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9325050 | http://www.w3.org/2000/01/rdf-schema#comment | "Overlapping DNA fragments spanning approximately 21 kb of genomic DNA and encompassing the human 4-hydroxyphenylpyruvate dioxygenase gene (HPD) have been cloned by screening a human leukocyte genomic library and by PCR amplification of human fibroblastic DNA. A continuous gene sequence of 20,890 nucleotides was established, including 1957 bp of the 5'-flanking region. The 4-hydroxyphenylpyruvate dioxygenase gene is composed of 14 exons interrupted by 13 introns, all exhibiting conventional vertebrate splicing. Computer analysis of the DNA sequence revealed 12 complete repetitive Alu elements, 1 in the 5'-flanking region and 11 in the intervening segments of the gene. The transcriptional initiation site was mapped to a position 35 nt upstream of the translational start point. The computer analysis also identified several potential transcription regulatory elements, including one CRE site, two AP-2 sites, and two Sp1 sites, in the sequence upstream of the transcription initiation site. Functional analysis of promoter activity by transient transfection of chloramphenicolacetyl transferase reporter plasmids revealed a possible involvement of cyclic adenosine monophosphate in the regulation of transcription. The highest level of expression of 4-hydroxyphenylpyruvate dioxygenase was found in human liver tissue as demonstrated by Northern blot analysis."xsd:string |
| http://purl.uniprot.org/citations/9325050 | http://purl.org/dc/terms/identifier | "doi:10.1006/geno.1997.4887"xsd:string |
| http://purl.uniprot.org/citations/9325050 | http://purl.org/dc/terms/identifier | "doi:10.1006/geno.1997.4887"xsd:string |
| http://purl.uniprot.org/citations/9325050 | http://purl.uniprot.org/core/author | "Lindstedt S."xsd:string |
| http://purl.uniprot.org/citations/9325050 | http://purl.uniprot.org/core/author | "Lindstedt S."xsd:string |
| http://purl.uniprot.org/citations/9325050 | http://purl.uniprot.org/core/author | "Ruetschi U."xsd:string |
| http://purl.uniprot.org/citations/9325050 | http://purl.uniprot.org/core/author | "Ruetschi U."xsd:string |
| http://purl.uniprot.org/citations/9325050 | http://purl.uniprot.org/core/author | "Rymo L."xsd:string |
| http://purl.uniprot.org/citations/9325050 | http://purl.uniprot.org/core/author | "Rymo L."xsd:string |
| http://purl.uniprot.org/citations/9325050 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9325050 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9325050 | http://purl.uniprot.org/core/name | "Genomics"xsd:string |
| http://purl.uniprot.org/citations/9325050 | http://purl.uniprot.org/core/name | "Genomics"xsd:string |
| http://purl.uniprot.org/citations/9325050 | http://purl.uniprot.org/core/pages | "292-299"xsd:string |
| http://purl.uniprot.org/citations/9325050 | http://purl.uniprot.org/core/pages | "292-299"xsd:string |
| http://purl.uniprot.org/citations/9325050 | http://purl.uniprot.org/core/title | "Human 4-hydroxyphenylpyruvate dioxygenase gene (HPD)."xsd:string |
| http://purl.uniprot.org/citations/9325050 | http://purl.uniprot.org/core/title | "Human 4-hydroxyphenylpyruvate dioxygenase gene (HPD)."xsd:string |
| http://purl.uniprot.org/citations/9325050 | http://purl.uniprot.org/core/volume | "44"xsd:string |
| http://purl.uniprot.org/citations/9325050 | http://purl.uniprot.org/core/volume | "44"xsd:string |
| http://purl.uniprot.org/citations/9325050 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9325050 |
| http://purl.uniprot.org/citations/9325050 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9325050 |
| http://purl.uniprot.org/citations/9325050 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9325050 |
| http://purl.uniprot.org/citations/9325050 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9325050 |