| http://purl.uniprot.org/citations/9326583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9326583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9326583 | http://www.w3.org/2000/01/rdf-schema#comment | "Subcellular localization directed by specific A kinase anchoring proteins (AKAPs) is a mechanism for compartmentalization of cAMP-dependent protein kinase (PKA). Using a two-hybrid screen, a novel AKAP was isolated. Because it interacts with both the type I and type II regulatory subunits, it was defined as a dual specific AKAP or D-AKAP1. Here we report the cloning and characterization of another novel cDNA isolated from that screen. This new member of the D-AKAP family, D-AKAP2, also binds both types of regulatory subunits. A message of 5 kb pairs was detected for D-AKAP2 in all embryonic stages and in all adult tissues tested. In brain, skeletal muscle, kidney, and testis, a 10-kb mRNA was identified. In testis, several small mRNAs were observed. Therefore, D-AKAP2 represents a novel family of proteins. cDNA cloning from a mouse testis library identified the full length D-AKAP2. It is composed of 372 amino acids which includes the R binding fragment, residues 333-372, at its C-terminus. Based on coprecipitation assays, the R binding domain interacts with the N-terminal dimerization domain of RIalpha and RIIalpha. A putative RGS domain was identified near the N-terminal region of D-AKAP2. The presence of this domain raises the intriguing possibility that D-AKAP2 may interact with a Galpha protein thus providing a link between the signaling machinery at the plasma membrane and the downstream kinase."xsd:string |
| http://purl.uniprot.org/citations/9326583 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.94.21.11184"xsd:string |
| http://purl.uniprot.org/citations/9326583 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.94.21.11184"xsd:string |
| http://purl.uniprot.org/citations/9326583 | http://purl.uniprot.org/core/author | "Taylor S.S."xsd:string |
| http://purl.uniprot.org/citations/9326583 | http://purl.uniprot.org/core/author | "Taylor S.S."xsd:string |
| http://purl.uniprot.org/citations/9326583 | http://purl.uniprot.org/core/author | "Chun J."xsd:string |
| http://purl.uniprot.org/citations/9326583 | http://purl.uniprot.org/core/author | "Chun J."xsd:string |
| http://purl.uniprot.org/citations/9326583 | http://purl.uniprot.org/core/author | "Durick K."xsd:string |
| http://purl.uniprot.org/citations/9326583 | http://purl.uniprot.org/core/author | "Durick K."xsd:string |
| http://purl.uniprot.org/citations/9326583 | http://purl.uniprot.org/core/author | "Huang L.J.-S."xsd:string |
| http://purl.uniprot.org/citations/9326583 | http://purl.uniprot.org/core/author | "Huang L.J.-S."xsd:string |
| http://purl.uniprot.org/citations/9326583 | http://purl.uniprot.org/core/author | "Weiner J.A."xsd:string |
| http://purl.uniprot.org/citations/9326583 | http://purl.uniprot.org/core/author | "Weiner J.A."xsd:string |
| http://purl.uniprot.org/citations/9326583 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9326583 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9326583 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/9326583 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/9326583 | http://purl.uniprot.org/core/pages | "11184-11189"xsd:string |
| http://purl.uniprot.org/citations/9326583 | http://purl.uniprot.org/core/pages | "11184-11189"xsd:string |
| http://purl.uniprot.org/citations/9326583 | http://purl.uniprot.org/core/title | "D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain."xsd:string |
| http://purl.uniprot.org/citations/9326583 | http://purl.uniprot.org/core/title | "D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain."xsd:string |
| http://purl.uniprot.org/citations/9326583 | http://purl.uniprot.org/core/volume | "94"xsd:string |
| http://purl.uniprot.org/citations/9326583 | http://purl.uniprot.org/core/volume | "94"xsd:string |