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| http://purl.uniprot.org/citations/9326643 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutation of Bruton's tyrosine kinase (Btk) impairs B cell maturation and function and results in a clinical phenotype of X-linked agammaglobulinemia. Activation of Btk correlates with an increase in the phosphorylation of two regulatory Btk tyrosine residues. Y551 (site 1) within the Src homology type 1 (SH1) domain is transphosphorylated by the Src family tyrosine kinases. Y223 (site 2) is an autophosphorylation site within the Btk SH3 domain. Polyclonal, phosphopeptide-specific antibodies were developed to evaluate the phosphorylation of Btk sites 1 and 2. Crosslinking of the B cell antigen receptor (BCR) or the mast cell Fcepsilon receptor, or interleukin 5 receptor stimulation each induced rapid phosphorylation at Btk sites 1 and 2 in a tightly coupled manner. Btk molecules were singly and doubly tyrosine-phosphorylated. Phosphorylated Btk comprised only a small fraction (xsd:string |
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| http://purl.uniprot.org/citations/9326643 | http://purl.uniprot.org/core/author | "Park H."xsd:string |
| http://purl.uniprot.org/citations/9326643 | http://purl.uniprot.org/core/author | "Witte O.N."xsd:string |
| http://purl.uniprot.org/citations/9326643 | http://purl.uniprot.org/core/author | "Fluckiger A.C."xsd:string |
| http://purl.uniprot.org/citations/9326643 | http://purl.uniprot.org/core/author | "Kato R.M."xsd:string |
| http://purl.uniprot.org/citations/9326643 | http://purl.uniprot.org/core/author | "Rawlings D.J."xsd:string |
| http://purl.uniprot.org/citations/9326643 | http://purl.uniprot.org/core/author | "Wahl M.I."xsd:string |
| http://purl.uniprot.org/citations/9326643 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9326643 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/9326643 | http://purl.uniprot.org/core/pages | "11526-11533"xsd:string |
| http://purl.uniprot.org/citations/9326643 | http://purl.uniprot.org/core/title | "Phosphorylation of two regulatory tyrosine residues in the activation of Bruton's tyrosine kinase via alternative receptors."xsd:string |
| http://purl.uniprot.org/citations/9326643 | http://purl.uniprot.org/core/volume | "94"xsd:string |
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