| http://purl.uniprot.org/citations/9341143 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9341143 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9341143 | http://www.w3.org/2000/01/rdf-schema#comment | "The mammalian translation initiation factor 3 (eIF3), is a multiprotein complex of approximately 600 kDa that binds to the 40 S ribosome and promotes the binding of methionyl-tRNAi and mRNA. cDNAs encoding 5 of the 10 subunits, namely eIF3-p170, -p116, -p110, -p48, and -p36, have been isolated previously. Here we report the cloning and characterization of human cDNAs encoding the major RNA binding subunit, eIF3-p66, and two additional subunits, eIF3-p47 and eIF3-p40. Each of these proteins is present in immunoprecipitates formed with affinity-purified anti-eIF3-p170 antibodies. Human eIF3-p66 shares 64% sequence identity with a hypothetical Caenorhabditis elegans protein, presumably the p66 homolog. Deletion analyses of recombinant derivatives of eIF3-p66 show that the RNA-binding domain lies within an N-terminal 71-amino acid region rich in lysine and arginine. The N-terminal regions of human eIF3-p40 and eIF3-p47 are related to each other and to 17 other eukaryotic proteins, including murine Mov-34, a subunit of the 26 S proteasome. Phylogenetic analyses of the 19 related protein sequences, called the Mov-34 family, distinguish five major subgroups, where eIF3-p40, eIF3-p47, and Mov-34 are each found in a different subgroup. The subunit composition of eIF3 appears to be highly conserved in Drosophila melanogaster, C. elegans, and Arabidopsis thaliana, whereas only 5 homologs of the 10 subunits of mammalian eIF3 are encoded in S. cerevisiae."xsd:string |
| http://purl.uniprot.org/citations/9341143 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.272.43.27042"xsd:string |
| http://purl.uniprot.org/citations/9341143 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.272.43.27042"xsd:string |
| http://purl.uniprot.org/citations/9341143 | http://purl.uniprot.org/core/author | "Asano K."xsd:string |
| http://purl.uniprot.org/citations/9341143 | http://purl.uniprot.org/core/author | "Asano K."xsd:string |
| http://purl.uniprot.org/citations/9341143 | http://purl.uniprot.org/core/author | "Hinnebusch A.G."xsd:string |
| http://purl.uniprot.org/citations/9341143 | http://purl.uniprot.org/core/author | "Hinnebusch A.G."xsd:string |
| http://purl.uniprot.org/citations/9341143 | http://purl.uniprot.org/core/author | "Hershey J.W.B."xsd:string |
| http://purl.uniprot.org/citations/9341143 | http://purl.uniprot.org/core/author | "Hershey J.W.B."xsd:string |
| http://purl.uniprot.org/citations/9341143 | http://purl.uniprot.org/core/author | "Vornlocher H.-P."xsd:string |
| http://purl.uniprot.org/citations/9341143 | http://purl.uniprot.org/core/author | "Vornlocher H.-P."xsd:string |
| http://purl.uniprot.org/citations/9341143 | http://purl.uniprot.org/core/author | "Merrick W.C."xsd:string |
| http://purl.uniprot.org/citations/9341143 | http://purl.uniprot.org/core/author | "Merrick W.C."xsd:string |
| http://purl.uniprot.org/citations/9341143 | http://purl.uniprot.org/core/author | "Richter-Cook N.J."xsd:string |
| http://purl.uniprot.org/citations/9341143 | http://purl.uniprot.org/core/author | "Richter-Cook N.J."xsd:string |
| http://purl.uniprot.org/citations/9341143 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9341143 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9341143 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9341143 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9341143 | http://purl.uniprot.org/core/pages | "27042-27052"xsd:string |
| http://purl.uniprot.org/citations/9341143 | http://purl.uniprot.org/core/pages | "27042-27052"xsd:string |
| http://purl.uniprot.org/citations/9341143 | http://purl.uniprot.org/core/title | "Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly."xsd:string |
| http://purl.uniprot.org/citations/9341143 | http://purl.uniprot.org/core/title | "Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly."xsd:string |