| http://purl.uniprot.org/citations/9342058 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9342058 | http://www.w3.org/2000/01/rdf-schema#comment | "Communications between the germline and the soma during Drosophila oogenesis have been previously shown to be essential for the formation of egg chambers and to establish polarity in the developing oocyte. In this report, we demonstrate that the function of a somatically expressed gene, cut, is critical for maintaining the structural integrity of germline-derived cells and their arrangement within an egg chamber. Genetic manipulations of cut activity resulted in defective packaging of germline-derived cysts into egg chambers and disintegration of the structural organization of oocyte-nurse cell complexes to generate multinucleate germline-derived cells. We also found that cut interacts genetically with the Notch gene and with the catalytic subunit of Protein kinase A gene during egg chamber morphogenesis. Since cut expression is restricted to the somatic follicle cells and cut mutant germline clones are phenotypically normal, we propose that the defects in the assembly of egg chambers and the changes in germline cell morphology observed in cut mutant egg chambers are the result of altered interactions between follicle cells and germline cells. cut encodes a nuclear protein containing DNA-binding motifs, and we suggest that it participates in intercellular communications by regulating the expression of molecules that directly participate in this process."xsd:string |
| http://purl.uniprot.org/citations/9342058 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.124.18.3663"xsd:string |
| http://purl.uniprot.org/citations/9342058 | http://purl.uniprot.org/core/author | "Jackson S.M."xsd:string |
| http://purl.uniprot.org/citations/9342058 | http://purl.uniprot.org/core/author | "Blochlinger K."xsd:string |
| http://purl.uniprot.org/citations/9342058 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9342058 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/9342058 | http://purl.uniprot.org/core/pages | "3663-3672"xsd:string |
| http://purl.uniprot.org/citations/9342058 | http://purl.uniprot.org/core/title | "cut interacts with Notch and protein kinase A to regulate egg chamber formation and to maintain germline cyst integrity during Drosophila oogenesis."xsd:string |
| http://purl.uniprot.org/citations/9342058 | http://purl.uniprot.org/core/volume | "124"xsd:string |
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