| http://purl.uniprot.org/citations/9348299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9348299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9348299 | http://www.w3.org/2000/01/rdf-schema#comment | "The murine interleukin 4 receptor (IL-4R) exists as a transmembrane protein transducing pleiotropic IL-4 functions, or as soluble (s)IL-4-binding molecule with potent immunoregulatory effects. In this study we identified and characterized a murine IL-4R allotype. Sequence analysis of the IL-4R cDNA of BALB/c mice revealed 18 base substitutions leading to three extracellular and five cytoplasmic amino acid changes when compared with the published IL-4R sequence of C57BL/6 mice. Analyses with allotype-specific mAbs revealed that AKR/J and SJL/J mice possess the newly identified BALB/c IL-4R allotype whereas the IL-4Rs of C3H, CBA, DBA-2, and FVB/N mice are identical to that of the C57BL/6 mouse. The extracellular Thr49 to Ile substitution abrogates one N-glycosylation site in the naturally occurring BALB/c IL-4R as well as in the experimentally point mutated C57BL/6-T49I sIL-4R, and both molecules display a nearly threefold reduction in IL-4-neutralizing activity compared to the C57BL/6 sIL-4R. In line with this, a significantly enhanced dissociation rate of IL-4 was detected for the BALB/c IL-4R allotype by surface plasmon resonance and in radioligand binding studies with IL-4R-transfected cell lines. These findings suggest that the altered ligand binding behavior of the newly described IL-4R allotype may influence the IL-4 responsiveness, thus contributing to the diverse phenotypes of inbred mouse strains in IL-4-dependent diseases."xsd:string |
| http://purl.uniprot.org/citations/9348299 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.186.9.1419"xsd:string |
| http://purl.uniprot.org/citations/9348299 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.186.9.1419"xsd:string |
| http://purl.uniprot.org/citations/9348299 | http://purl.uniprot.org/core/author | "Gessner A."xsd:string |
| http://purl.uniprot.org/citations/9348299 | http://purl.uniprot.org/core/author | "Gessner A."xsd:string |
| http://purl.uniprot.org/citations/9348299 | http://purl.uniprot.org/core/author | "Schulte T."xsd:string |
| http://purl.uniprot.org/citations/9348299 | http://purl.uniprot.org/core/author | "Schulte T."xsd:string |
| http://purl.uniprot.org/citations/9348299 | http://purl.uniprot.org/core/author | "Roellinghoff M."xsd:string |
| http://purl.uniprot.org/citations/9348299 | http://purl.uniprot.org/core/author | "Roellinghoff M."xsd:string |
| http://purl.uniprot.org/citations/9348299 | http://purl.uniprot.org/core/author | "Kurrle R."xsd:string |
| http://purl.uniprot.org/citations/9348299 | http://purl.uniprot.org/core/author | "Kurrle R."xsd:string |
| http://purl.uniprot.org/citations/9348299 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9348299 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9348299 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/9348299 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/9348299 | http://purl.uniprot.org/core/pages | "1419-1429"xsd:string |
| http://purl.uniprot.org/citations/9348299 | http://purl.uniprot.org/core/pages | "1419-1429"xsd:string |
| http://purl.uniprot.org/citations/9348299 | http://purl.uniprot.org/core/title | "Molecular characterization and functional analysis of murine interleukin 4 receptor allotypes."xsd:string |
| http://purl.uniprot.org/citations/9348299 | http://purl.uniprot.org/core/title | "Molecular characterization and functional analysis of murine interleukin 4 receptor allotypes."xsd:string |
| http://purl.uniprot.org/citations/9348299 | http://purl.uniprot.org/core/volume | "186"xsd:string |
| http://purl.uniprot.org/citations/9348299 | http://purl.uniprot.org/core/volume | "186"xsd:string |
| http://purl.uniprot.org/citations/9348299 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9348299 |
| http://purl.uniprot.org/citations/9348299 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9348299 |