| http://purl.uniprot.org/citations/9362539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9362539 | http://www.w3.org/2000/01/rdf-schema#comment | "Granzyme (gzm) A and gzmB have been implicated in Fas-independent nucleolytic and cytolytic processes exerted by cytotoxic T (Tc) cells, but the underlying mechanism(s) remains unclear. In this study, we compare the potential of Tc and natural killer (NK) cells of mice deficient in both gzmA and B (gzmAxB-/-) with those from single knockout mice deficient in gzmA (-/-), gzmB (-/-), or perforin (-/-) to induce nuclear damage and lysis in target cells. With the exception of perforin-/-, all in vitro- and ex vivo-derived Tc and NK cell populations from the mutant strains induced 51Cr-release in target cells at levels and with kinetics similar to those of normal mice. This contrasts with their capacity to induce apoptotic nuclear damage in target cells. In gzmAxB-/-mice, Tc/NK-mediated target cell DNA fragmentation was not observed, even after extended incubation periods (10 h), but was normal in gzmA-deficient and only impaired in gzmB-deficient mice in short-term (2-4 h), but not long-term (4-10 h), nucleolytic assays. This suggests that gzmA and B are critical for Tc/NK granule-mediated nucleolysis, with gzmB being the main contributor, while target cell lysis is due solely to perforin and independent of both proteases."xsd:string |
| http://purl.uniprot.org/citations/9362539 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.186.10.1781"xsd:string |
| http://purl.uniprot.org/citations/9362539 | http://purl.uniprot.org/core/author | "Ebnet K."xsd:string |
| http://purl.uniprot.org/citations/9362539 | http://purl.uniprot.org/core/author | "Simon M.M."xsd:string |
| http://purl.uniprot.org/citations/9362539 | http://purl.uniprot.org/core/author | "Tschopp J."xsd:string |
| http://purl.uniprot.org/citations/9362539 | http://purl.uniprot.org/core/author | "Tran T."xsd:string |
| http://purl.uniprot.org/citations/9362539 | http://purl.uniprot.org/core/author | "Hausmann M."xsd:string |
| http://purl.uniprot.org/citations/9362539 | http://purl.uniprot.org/core/author | "Mullbacher A."xsd:string |
| http://purl.uniprot.org/citations/9362539 | http://purl.uniprot.org/core/author | "ThaHla R."xsd:string |
| http://purl.uniprot.org/citations/9362539 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9362539 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/9362539 | http://purl.uniprot.org/core/pages | "1781-1786"xsd:string |
| http://purl.uniprot.org/citations/9362539 | http://purl.uniprot.org/core/title | "In vitro- and ex vivo-derived cytolytic leukocytes from granzyme A x B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells."xsd:string |
| http://purl.uniprot.org/citations/9362539 | http://purl.uniprot.org/core/volume | "186"xsd:string |
| http://purl.uniprot.org/citations/9362539 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9362539 |
| http://purl.uniprot.org/citations/9362539 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9362539 |
| http://purl.uniprot.org/uniprot/#_P11032-mappedCitation-9362539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9362539 |
| http://purl.uniprot.org/uniprot/#_A2RSY7-mappedCitation-9362539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9362539 |
| http://purl.uniprot.org/uniprot/#_P04187-mappedCitation-9362539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9362539 |
| http://purl.uniprot.org/uniprot/#_Q3TZH4-mappedCitation-9362539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9362539 |
| http://purl.uniprot.org/uniprot/#_P10820-mappedCitation-9362539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9362539 |
| http://purl.uniprot.org/uniprot/#_Q3TIP3-mappedCitation-9362539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9362539 |
| http://purl.uniprot.org/uniprot/#_Q3UK79-mappedCitation-9362539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9362539 |
| http://purl.uniprot.org/uniprot/#_Q4FJY0-mappedCitation-9362539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9362539 |