| http://purl.uniprot.org/citations/9367984 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9367984 | http://www.w3.org/2000/01/rdf-schema#comment | "We analyzed the function of the downstream promoter element (DPE), a distinct 7-nucleotide core promoter element that is approximately 30 nucleotides downstream of the transcription start site of many TATA-box-deficient (TATA-less) promoters in Drosophila. There is a strict requirement for spacing between the Inr and DPE motifs, as an increase or decrease of 3 nucleotides in the distance between the Inr and DPE causes a seven-to eightfold reduction in transcription as well as a significant reduction in the binding of purified TFIID. These results suggest a specific and somewhat rigid interaction of TFIID with the Inr and DPE sequences. Photo-cross-linking analysis of purified TFIID with a TATA-less DPE-containing promoter revealed specific cross-linking of dTAFII60 and dTAFII40 to the DPE, with a higher efficiency of cross-linking to dTAFII60 than to dTAFII40. These data, combined with the previously well-characterized interactions between the two TAFs and their homology to histones H4 and H3, suggest that a dTAFII60-dTAFII40 heterotetramer binds to the DPE. Human and Drosophila transcription factors exhibit essentially the same requirements for DPE sequence and for Inr-DPE spacing. In addition, the TATA-less promoter of the human interferon regulatory factor-1 (IRF-1) gene contains a DPE that is important for transcriptional activity both in vitro and in cultured cells. Hence, these studies provide evidence for a direct role of TAFs in basal transcription of TATA-less DPE-containing genes and collectively indicate that the DPE is, in many respects, a downstream counterpart to the TATA box that is present in Drosophila to humans."xsd:string |
| http://purl.uniprot.org/citations/9367984 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.11.22.3020"xsd:string |
| http://purl.uniprot.org/citations/9367984 | http://purl.uniprot.org/core/author | "Kadonaga J.T."xsd:string |
| http://purl.uniprot.org/citations/9367984 | http://purl.uniprot.org/core/author | "Burke T.W."xsd:string |
| http://purl.uniprot.org/citations/9367984 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9367984 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/9367984 | http://purl.uniprot.org/core/pages | "3020-3031"xsd:string |
| http://purl.uniprot.org/citations/9367984 | http://purl.uniprot.org/core/title | "The downstream core promoter element, DPE, is conserved from Drosophila to humans and is recognized by TAFII60 of Drosophila."xsd:string |
| http://purl.uniprot.org/citations/9367984 | http://purl.uniprot.org/core/volume | "11"xsd:string |
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