http://purl.uniprot.org/citations/9370357 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/9370357 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/9370357 | http://www.w3.org/2000/01/rdf-schema#comment | "PCTAIRE are members of a subfamily of Cdc2-related kinases that have been shown to be preferentially expressed in post-mitotic cells. To examine the neural functions of PCTAIRE, rat cDNA clones encoding PCTAIRE 1, 2, and 3 were isolated, and their expression patterns in the brain were analyzed. Among the three rat PCTAIREs, only PCTAIRE 2 was found to be specifically expressed in the brain. Furthermore, its expression was transiently increased during brain development, peaking 7-15 days after birth. Within the brain, PCTAIRE 2 was concentrated in the neuronal layers of the hippocampus and olfactory bulb, which mostly consist of post-mitotic neurons. In an immunocytochemical experiment, immunoreactivity for PCTAIRE 2 was detected in the cell bodies and extended neurites of neurons, but not in astrocytes. The PCTAIRE 2 protein was recovered in the particulate fraction and resistant to solubilization with non-ionic detergent, suggesting that PCTAIRE 2 might be present as a component of a large protein complex. An immunoprecipitation assay revealed that the PCTAIRE 2 was associated with Ser/Thr-phosphorylating activity for histone H1, and that its activity depended on association with a regulatory partner that can be released under high-salt conditions. These findings suggest that PCTAIRE 2 is a Ser/Thr kinase that might play a unique role in terminally differentiated neurons."xsd:string |
http://purl.uniprot.org/citations/9370357 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1432-1033.1997.t01-1-00481.x"xsd:string |
http://purl.uniprot.org/citations/9370357 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1432-1033.1997.t01-1-00481.x"xsd:string |
http://purl.uniprot.org/citations/9370357 | http://purl.uniprot.org/core/author | "Hirose T."xsd:string |
http://purl.uniprot.org/citations/9370357 | http://purl.uniprot.org/core/author | "Hirose T."xsd:string |
http://purl.uniprot.org/citations/9370357 | http://purl.uniprot.org/core/author | "Nagai K."xsd:string |
http://purl.uniprot.org/citations/9370357 | http://purl.uniprot.org/core/author | "Nagai K."xsd:string |
http://purl.uniprot.org/citations/9370357 | http://purl.uniprot.org/core/author | "Okada M."xsd:string |
http://purl.uniprot.org/citations/9370357 | http://purl.uniprot.org/core/author | "Okada M."xsd:string |
http://purl.uniprot.org/citations/9370357 | http://purl.uniprot.org/core/author | "Okumura N."xsd:string |
http://purl.uniprot.org/citations/9370357 | http://purl.uniprot.org/core/author | "Okumura N."xsd:string |
http://purl.uniprot.org/citations/9370357 | http://purl.uniprot.org/core/author | "Tamaru T."xsd:string |
http://purl.uniprot.org/citations/9370357 | http://purl.uniprot.org/core/author | "Tamaru T."xsd:string |
http://purl.uniprot.org/citations/9370357 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
http://purl.uniprot.org/citations/9370357 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
http://purl.uniprot.org/citations/9370357 | http://purl.uniprot.org/core/name | "Eur. J. Biochem."xsd:string |
http://purl.uniprot.org/citations/9370357 | http://purl.uniprot.org/core/name | "Eur. J. Biochem."xsd:string |
http://purl.uniprot.org/citations/9370357 | http://purl.uniprot.org/core/pages | "481-488"xsd:string |
http://purl.uniprot.org/citations/9370357 | http://purl.uniprot.org/core/pages | "481-488"xsd:string |
http://purl.uniprot.org/citations/9370357 | http://purl.uniprot.org/core/title | "PCTAIRE 2, a Cdc2-related serine/threonine kinase, is predominantly expressed in terminally differentiated neurons."xsd:string |
http://purl.uniprot.org/citations/9370357 | http://purl.uniprot.org/core/title | "PCTAIRE 2, a Cdc2-related serine/threonine kinase, is predominantly expressed in terminally differentiated neurons."xsd:string |
http://purl.uniprot.org/citations/9370357 | http://purl.uniprot.org/core/volume | "249"xsd:string |
http://purl.uniprot.org/citations/9370357 | http://purl.uniprot.org/core/volume | "249"xsd:string |