| http://purl.uniprot.org/citations/9371501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9371501 | http://www.w3.org/2000/01/rdf-schema#comment | "Apc-associated intestinal tumor formation appears to require functional loss of both Apc alleles. Apc has, therefore, been classified as a tumor suppressor gene. Loss of APC protein function results in increased intracellular beta-catenin, a molecule important to both cell-cell adhesion and regulation of cellular growth. In mice bearing a germ-line Apc mutation, we found that enterocyte beta-catenin expression was also increased in histologically normal intestinal mucosa. Enterocyte crypt-villus migration was decreased by 25%, and treatment of Min/+ animals with sulindac sulfide normalized both beta-catenin expression and enterocyte migration. Our data suggest that alterations in enterocyte migration occur in cells bearing a single mutant Apc allele, and that sulindac sulfide may normalize enterocyte growth in these cells."xsd:string |
| http://purl.uniprot.org/citations/9371501 | http://purl.uniprot.org/core/author | "Martucci C."xsd:string |
| http://purl.uniprot.org/citations/9371501 | http://purl.uniprot.org/core/author | "Mahmoud N.N."xsd:string |
| http://purl.uniprot.org/citations/9371501 | http://purl.uniprot.org/core/author | "Bertagnolli M.M."xsd:string |
| http://purl.uniprot.org/citations/9371501 | http://purl.uniprot.org/core/author | "Boolbol S.K."xsd:string |
| http://purl.uniprot.org/citations/9371501 | http://purl.uniprot.org/core/author | "Chadburn A."xsd:string |
| http://purl.uniprot.org/citations/9371501 | http://purl.uniprot.org/core/author | "Bilinski R.T."xsd:string |
| http://purl.uniprot.org/citations/9371501 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9371501 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/9371501 | http://purl.uniprot.org/core/pages | "5045-5050"xsd:string |
| http://purl.uniprot.org/citations/9371501 | http://purl.uniprot.org/core/title | "Apc gene mutation is associated with a dominant-negative effect upon intestinal cell migration."xsd:string |
| http://purl.uniprot.org/citations/9371501 | http://purl.uniprot.org/core/volume | "57"xsd:string |
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