| http://purl.uniprot.org/citations/9371802 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9371802 | http://www.w3.org/2000/01/rdf-schema#comment | "Apolipoprotein B (apoB) mRNA editing catalyzed by apoB mRNA editing catalytic subunit 1 (APOBEC-1) has been proposed to be a nuclear process. To test this hypothesis, the subcellular distribution of hemagglutinin-(HA) tagged APOBEC-1 expressed in transiently transfected hepatoma cells was determined by indirect immunofluorescence microscopy. HA-APOBEC-1 was detected in both the nucleus and cytoplasm of rat and human hepatoma cells. Mutagenesis of APOBEC-1 demonstrated that the N-terminal 56 amino acids (1-56) were necessary for the nuclear distribution of APOBEC-1, but this region did not contain a functional nuclear localization signal (NLS). However, we identified a 24-amino acid domain in the C terminus of APOBEC-1 with characteristics of a cytoplasmic retention signal (CRS) or a nuclear export signal (NES). These data suggest, therefore, that the nuclear import of APOBEC-1 may not be mediated by a positive NLS; rather, it may be achieved by overcoming the effect of a CRS/NES. We also demonstrated that the nuclear distribution of APOBEC-1 occurred only in cell lines that were capable of editing apoB RNA. We propose that the cellular distribution of APOBEC-1 is determined by multiple domains within this protein, and a nuclear localization of the enzyme may be regulated by cell type-specific factors that render these cells uniquely editing competent."xsd:string |
| http://purl.uniprot.org/citations/9371802 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.94.24.13075"xsd:string |
| http://purl.uniprot.org/citations/9371802 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/9371802 | http://purl.uniprot.org/core/author | "Yang Y.'"xsd:string |
| http://purl.uniprot.org/citations/9371802 | http://purl.uniprot.org/core/author | "Smith H.C."xsd:string |
| http://purl.uniprot.org/citations/9371802 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9371802 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/9371802 | http://purl.uniprot.org/core/pages | "13075-13080"xsd:string |
| http://purl.uniprot.org/citations/9371802 | http://purl.uniprot.org/core/title | "Multiple protein domains determine the cell type-specific nuclear distribution of the catalytic subunit required for apolipoprotein B mRNA editing."xsd:string |
| http://purl.uniprot.org/citations/9371802 | http://purl.uniprot.org/core/volume | "94"xsd:string |
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