| http://purl.uniprot.org/citations/9374458 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9374458 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9374458 | http://www.w3.org/2000/01/rdf-schema#comment | "The interleukin-1 receptor (IL-1R) signaling pathway leads to nuclear factor kappa B (NF-kappaB) activation in mammals and is similar to the Toll pathway in Drosophila: the IL-1R-associated kinase (IRAK) is homologous to Pelle. Two additional proximal mediators were identified that are required for IL-1R-induced NF-kappaB activation: IRAK-2, a Pelle family member, and MyD88, a death domain-containing adapter molecule. Both associate with the IL-1R signaling complex. Dominant negative forms of either attenuate IL-1R-mediated NF-kappaB activation. Therefore, IRAK-2 and MyD88 may provide additional therapeutic targets for inhibiting IL-1-induced inflammation."xsd:string |
| http://purl.uniprot.org/citations/9374458 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.278.5343.1612"xsd:string |
| http://purl.uniprot.org/citations/9374458 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.278.5343.1612"xsd:string |
| http://purl.uniprot.org/citations/9374458 | http://purl.uniprot.org/core/author | "Ni J."xsd:string |
| http://purl.uniprot.org/citations/9374458 | http://purl.uniprot.org/core/author | "Ni J."xsd:string |
| http://purl.uniprot.org/citations/9374458 | http://purl.uniprot.org/core/author | "Feng P."xsd:string |
| http://purl.uniprot.org/citations/9374458 | http://purl.uniprot.org/core/author | "Feng P."xsd:string |
| http://purl.uniprot.org/citations/9374458 | http://purl.uniprot.org/core/author | "Dixit V.M."xsd:string |
| http://purl.uniprot.org/citations/9374458 | http://purl.uniprot.org/core/author | "Dixit V.M."xsd:string |
| http://purl.uniprot.org/citations/9374458 | http://purl.uniprot.org/core/author | "Muzio M."xsd:string |
| http://purl.uniprot.org/citations/9374458 | http://purl.uniprot.org/core/author | "Muzio M."xsd:string |
| http://purl.uniprot.org/citations/9374458 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9374458 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9374458 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/9374458 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/9374458 | http://purl.uniprot.org/core/pages | "1612-1615"xsd:string |
| http://purl.uniprot.org/citations/9374458 | http://purl.uniprot.org/core/pages | "1612-1615"xsd:string |
| http://purl.uniprot.org/citations/9374458 | http://purl.uniprot.org/core/title | "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling."xsd:string |
| http://purl.uniprot.org/citations/9374458 | http://purl.uniprot.org/core/title | "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling."xsd:string |
| http://purl.uniprot.org/citations/9374458 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/9374458 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/9374458 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9374458 |
| http://purl.uniprot.org/citations/9374458 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9374458 |