| http://purl.uniprot.org/citations/9378559 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9378559 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9378559 | http://www.w3.org/2000/01/rdf-schema#comment | "Analysis of t(X;18) translocation in synovial sarcoma had previously led to the definition of the SSX2 gene, the fusion partner on chromosome X. Subsequent screening of testicular cDNA libraries identified 2 highly homologous genes, SSX1 and SSX3. Among these 3 genes, SSX2 has been found to be identical to HOM-MEL-40, which codes for an immunogenic tumor antigen expressed in various human cancers. SSX2 thus belongs to the family of cancer/testis (CT) antigens, i.e., immunogenic protein antigens with characteristic mRNA expression in normal testis and in cancer. To define additional CT antigens, we have immuno-screened a testicular cDNA expression library with an allogeneic serum from a melanoma patient, and both SSX2 and SSX3 were isolated. Further studies using testicular cDNA and SSX probes defined 2 new members of this gene family, SSX4 and SSX5, while a shorter cDNA variant of SSX4 was also identified. All 5 members of the SSX family shared strong sequence homology, with nucleotide homology ranging from 88 to 95% and amino acid homology ranging from 77 to 91%. Genomic cloning of a prototype SSX gene (SSX2) showed that its coding region is encoded by 6 exons, and the shortened form of SSX4 cDNA represents an alternatively spliced product lacking the 5th exon. Analysis of SSX mRNA expression by gene-specific RT-PCR confirmed that all 5 SSX genes are expressed in testis. In addition, analysis of a panel of 12 melanoma cell lines showed strong mRNA expression of either SSX1 (3/12), SSX2 (3/12), SSX4 (1/12), or SSX5 (1/12), indicating variable activation of the genes in malignant cells."xsd:string |
| http://purl.uniprot.org/citations/9378559 | http://purl.org/dc/terms/identifier | "doi:10.1002/(sici)1097-0215(19970917)72:6<965::aid-ijc8>3.0.co;2-n"xsd:string |
| http://purl.uniprot.org/citations/9378559 | http://purl.org/dc/terms/identifier | "doi:10.1002/(sici)1097-0215(19970917)72:6<965::aid-ijc8>3.0.co;2-n"xsd:string |
| http://purl.uniprot.org/citations/9378559 | http://purl.uniprot.org/core/author | "Chen Y.-T."xsd:string |
| http://purl.uniprot.org/citations/9378559 | http://purl.uniprot.org/core/author | "Chen Y.-T."xsd:string |
| http://purl.uniprot.org/citations/9378559 | http://purl.uniprot.org/core/author | "Gure A.O."xsd:string |
| http://purl.uniprot.org/citations/9378559 | http://purl.uniprot.org/core/author | "Gure A.O."xsd:string |
| http://purl.uniprot.org/citations/9378559 | http://purl.uniprot.org/core/author | "Knuth A."xsd:string |
| http://purl.uniprot.org/citations/9378559 | http://purl.uniprot.org/core/author | "Knuth A."xsd:string |
| http://purl.uniprot.org/citations/9378559 | http://purl.uniprot.org/core/author | "Old L.J."xsd:string |
| http://purl.uniprot.org/citations/9378559 | http://purl.uniprot.org/core/author | "Old L.J."xsd:string |
| http://purl.uniprot.org/citations/9378559 | http://purl.uniprot.org/core/author | "Scanlan M.J."xsd:string |
| http://purl.uniprot.org/citations/9378559 | http://purl.uniprot.org/core/author | "Scanlan M.J."xsd:string |
| http://purl.uniprot.org/citations/9378559 | http://purl.uniprot.org/core/author | "Sahin U."xsd:string |
| http://purl.uniprot.org/citations/9378559 | http://purl.uniprot.org/core/author | "Sahin U."xsd:string |
| http://purl.uniprot.org/citations/9378559 | http://purl.uniprot.org/core/author | "Tuereci O."xsd:string |
| http://purl.uniprot.org/citations/9378559 | http://purl.uniprot.org/core/author | "Tuereci O."xsd:string |
| http://purl.uniprot.org/citations/9378559 | http://purl.uniprot.org/core/author | "Pfreundschuh M."xsd:string |
| http://purl.uniprot.org/citations/9378559 | http://purl.uniprot.org/core/author | "Pfreundschuh M."xsd:string |
| http://purl.uniprot.org/citations/9378559 | http://purl.uniprot.org/core/author | "Tsang S."xsd:string |
| http://purl.uniprot.org/citations/9378559 | http://purl.uniprot.org/core/author | "Tsang S."xsd:string |
| http://purl.uniprot.org/citations/9378559 | http://purl.uniprot.org/core/author | "Jager E."xsd:string |
| http://purl.uniprot.org/citations/9378559 | http://purl.uniprot.org/core/author | "Jager E."xsd:string |