| http://purl.uniprot.org/citations/9378960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9378960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9378960 | http://www.w3.org/2000/01/rdf-schema#comment | "CD5 is a 67-kDa T cell surface Ag that can be found physically associated with the CD3-TCR molecular complex. In different experimental models it has been shown to act as a costimulatory receptor for T cell activation. Unexpectedly, studies in CD5-deficient mice suggested a negative role for the CD5 Ag in CD3-TCR signaling in the thymus. In this report we assessed the constitutive interactions of CD5 in freshly isolated human thymocytes with signaling elements of the CD3-TCR complex. We determined that the ZAP-70 protein tyrosine kinase was present in CD5 immunoprecipitates. The two molecules were constitutively tyrosine phosphorylated in a complex also associating with unphosphorylated as well as phosphorylated zeta-chains. Although both p21 and p23 tyrosine-phosphorylated forms of zeta as well as phospho-CD3 epsilon molecules were constitutively present in human thymocytes and could be immunoprecipitated with ZAP-70- or CD3 epsilon-specific Abs, the p21 species of zeta was predominant in CD5 immune complexes. The interaction between CD5 and ZAP-70 was not observed in CD3-negative thymocytes, where the constitutive tyrosine phosphorylation of ZAP-70 was very low. We conclude that CD5 may affect in vivo the signaling capacity of TCRs expressed by human thymocytes by altering the phosphorylation state of CD3 and/or by retaining ZAP-70 with the p21 species of zeta."xsd:string |
| http://purl.uniprot.org/citations/9378960 | http://purl.uniprot.org/core/author | "Lang V."xsd:string |
| http://purl.uniprot.org/citations/9378960 | http://purl.uniprot.org/core/author | "Lang V."xsd:string |
| http://purl.uniprot.org/citations/9378960 | http://purl.uniprot.org/core/author | "Boumsell L."xsd:string |
| http://purl.uniprot.org/citations/9378960 | http://purl.uniprot.org/core/author | "Boumsell L."xsd:string |
| http://purl.uniprot.org/citations/9378960 | http://purl.uniprot.org/core/author | "Bismuth G."xsd:string |
| http://purl.uniprot.org/citations/9378960 | http://purl.uniprot.org/core/author | "Bismuth G."xsd:string |
| http://purl.uniprot.org/citations/9378960 | http://purl.uniprot.org/core/author | "Gary-Gouy H."xsd:string |
| http://purl.uniprot.org/citations/9378960 | http://purl.uniprot.org/core/author | "Gary-Gouy H."xsd:string |
| http://purl.uniprot.org/citations/9378960 | http://purl.uniprot.org/core/author | "Sarun S."xsd:string |
| http://purl.uniprot.org/citations/9378960 | http://purl.uniprot.org/core/author | "Sarun S."xsd:string |
| http://purl.uniprot.org/citations/9378960 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9378960 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9378960 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/9378960 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/9378960 | http://purl.uniprot.org/core/pages | "3739-3747"xsd:string |
| http://purl.uniprot.org/citations/9378960 | http://purl.uniprot.org/core/pages | "3739-3747"xsd:string |
| http://purl.uniprot.org/citations/9378960 | http://purl.uniprot.org/core/title | "In vivo association of CD5 with tyrosine-phosphorylated ZAP-70 and p21 phospho-zeta molecules in human CD3+ thymocytes."xsd:string |
| http://purl.uniprot.org/citations/9378960 | http://purl.uniprot.org/core/title | "In vivo association of CD5 with tyrosine-phosphorylated ZAP-70 and p21 phospho-zeta molecules in human CD3+ thymocytes."xsd:string |
| http://purl.uniprot.org/citations/9378960 | http://purl.uniprot.org/core/volume | "159"xsd:string |
| http://purl.uniprot.org/citations/9378960 | http://purl.uniprot.org/core/volume | "159"xsd:string |
| http://purl.uniprot.org/citations/9378960 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9378960 |
| http://purl.uniprot.org/citations/9378960 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9378960 |