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http://purl.uniprot.org/citations/9382366http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9382366http://www.w3.org/2000/01/rdf-schema#comment"

Background

Heterozygosity for a 32-nucleotide deletion in the C-C chemokine receptor 5 gene (CCR5 delta 32) is associated with delayed disease progression in persons infected with HIV-1.

Objective

To compare the predictive value of CCR5 genotype with that of established markers in the clinical course of HIV-1 infection.

Design

Retrospective longitudinal study and nested case-control study. The latter included only long-term survivors, who were individually matched with progressors.

Setting

Amsterdam, the Netherlands.

Participants

364 homosexual men with HIV-1 infection.

Measurements

Polymerase chain reaction was used for CCR5 genotyping. Univariate and multivariate Cox proportional hazard analyses were done for disease progression with CCR5 genotype, CD4+ T-lymphocyte counts, T-lymphocyte function, HIV-1 biological phenotype (syncytium-inducing or non-syncytium-inducing HIV-1), and viral RNA load in serum as covariates.

Results

In the case-control study, 48% of long-term survivors were heterozygous for CCR5 delta 32 compared with 9% of progressors (odds ratio, 6.9 [95% CI, 1.9 to 24.8]). In the total study sample, CCR5 delta 32 heterozygotes had significantly delayed disease progression (P < 0.001; relative hazard, 0.4 [CI, 0.3 to 0.6]), a 1.5-fold slower decrease in CD4+ T-lymphocyte count (P = 0.01), and a 2.6-fold lower viral RNA load (P = 0.01) at approximately 2.3 years after seroconversion compared with CCR5 wild-type homozygotes. At the end of the study, both groups showed the same prevalence of syncytium-inducing HIV-1, but CCR5 delta 32 heterozygotes had a delayed conversion rate. The protective effect of CCR5 delta 32 heterozygosity was stronger in the presence of only non-syncytium-inducing HIV-1. The CCR5 genotype predicted disease progression independent of viral RNA load, CD4+ T-lymphocyte counts, T-lymphocyte function, and HIV-1 biological phenotype.

Conclusions

The addition of CCR5 genotype to currently available laboratory markers may allow better estimation of the clinical course of HIV-1 infection."xsd:string
http://purl.uniprot.org/citations/9382366http://purl.org/dc/terms/identifier"doi:10.7326/0003-4819-127-10-199711150-00004"xsd:string
http://purl.uniprot.org/citations/9382366http://purl.uniprot.org/core/author"Cornelissen M."xsd:string
http://purl.uniprot.org/citations/9382366http://purl.uniprot.org/core/author"Schuitemaker H."xsd:string
http://purl.uniprot.org/citations/9382366http://purl.uniprot.org/core/author"Prins M."xsd:string
http://purl.uniprot.org/citations/9382366http://purl.uniprot.org/core/author"Goudsmit J."xsd:string
http://purl.uniprot.org/citations/9382366http://purl.uniprot.org/core/author"Bakker M."xsd:string
http://purl.uniprot.org/citations/9382366http://purl.uniprot.org/core/author"Miedema F."xsd:string
http://purl.uniprot.org/citations/9382366http://purl.uniprot.org/core/author"Brouwer M."xsd:string
http://purl.uniprot.org/citations/9382366http://purl.uniprot.org/core/author"de Roda Husman A.M."xsd:string
http://purl.uniprot.org/citations/9382366http://purl.uniprot.org/core/author"Coutinho R.A."xsd:string
http://purl.uniprot.org/citations/9382366http://purl.uniprot.org/core/author"de Wolf F."xsd:string
http://purl.uniprot.org/citations/9382366http://purl.uniprot.org/core/author"Koot M."xsd:string
http://purl.uniprot.org/citations/9382366http://purl.uniprot.org/core/author"Broersen S.M."xsd:string
http://purl.uniprot.org/citations/9382366http://purl.uniprot.org/core/author"Keet I.P."xsd:string
http://purl.uniprot.org/citations/9382366http://purl.uniprot.org/core/author"Roos M.T."xsd:string
http://purl.uniprot.org/citations/9382366http://purl.uniprot.org/core/date"1997"xsd:gYear
http://purl.uniprot.org/citations/9382366http://purl.uniprot.org/core/name"Ann Intern Med"xsd:string
http://purl.uniprot.org/citations/9382366http://purl.uniprot.org/core/pages"882-890"xsd:string
http://purl.uniprot.org/citations/9382366http://purl.uniprot.org/core/title"Association between CCR5 genotype and the clinical course of HIV-1 infection."xsd:string
http://purl.uniprot.org/citations/9382366http://purl.uniprot.org/core/volume"127"xsd:string
http://purl.uniprot.org/citations/9382366http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/9382366
http://purl.uniprot.org/citations/9382366http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/9382366
http://purl.uniprot.org/uniprot/#_A0A089G6S6-mappedCitation-9382366http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9382366
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