| http://purl.uniprot.org/citations/9383054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9383054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9383054 | http://www.w3.org/2000/01/rdf-schema#comment | "The gonad of the Caenorhabditis elegans hermaphrodite is generated by the postembryonic divisions of two somatic precursors, Z1 and Z4, and two germline precursors, Z2 and Z3. These cells begin division midway through the first larval stage. By the end of the fourth larval stage, Z1 and Z4 produce 143 descendants, while Z2 and Z3 give rise to approximately 1000 descendants. The divisions of Z2 and Z3 are dependent on signals produced by Z1 and Z4, but not vice versa. We have characterized the properties of five loss-of-function alleles of a newly described gene, which we call gon-2. In gon-2 mutants, gonadogenesis is severely impaired; in some animals, none of the gonad progenitors undergo any postembryonic divisions. Mutations in gon-2 have a partial maternal effect: either maternal or zygotic expression is sufficient to prevent the severe gonadogenesis defects. By cell lineage analysis, we found that the priman, defect in gon-2 mutants is a delay (sometimes a complete block) in the onset and continuation of gonadal divisions. The results of upshift experiments using a temperature-sensitive allele suggest that zygotic expression of gon-2 begins early in embryogenesis, before the birth of Z1 and Z4. The results of downshift experiments suggest that Z1 and Z4 can generate the full complement of gonadal tissues even when gon-2 function is inhibited until the end of the second larval stage. Thus, gon-2 activity is probably not required for the specification of gonadal cell fates, but appears to be generally required for gonadal cell divisions."xsd:string |
| http://purl.uniprot.org/citations/9383054 | http://purl.org/dc/terms/identifier | "doi:10.1093/genetics/147.3.1077"xsd:string |
| http://purl.uniprot.org/citations/9383054 | http://purl.org/dc/terms/identifier | "doi:10.1093/genetics/147.3.1077"xsd:string |
| http://purl.uniprot.org/citations/9383054 | http://purl.uniprot.org/core/author | "Sun A.Y."xsd:string |
| http://purl.uniprot.org/citations/9383054 | http://purl.uniprot.org/core/author | "Sun A.Y."xsd:string |
| http://purl.uniprot.org/citations/9383054 | http://purl.uniprot.org/core/author | "Lambie E.J."xsd:string |
| http://purl.uniprot.org/citations/9383054 | http://purl.uniprot.org/core/author | "Lambie E.J."xsd:string |
| http://purl.uniprot.org/citations/9383054 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9383054 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9383054 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/9383054 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/9383054 | http://purl.uniprot.org/core/pages | "1077-1089"xsd:string |
| http://purl.uniprot.org/citations/9383054 | http://purl.uniprot.org/core/pages | "1077-1089"xsd:string |
| http://purl.uniprot.org/citations/9383054 | http://purl.uniprot.org/core/title | "gon-2, a gene required for gonadogenesis in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/9383054 | http://purl.uniprot.org/core/title | "gon-2, a gene required for gonadogenesis in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/9383054 | http://purl.uniprot.org/core/volume | "147"xsd:string |
| http://purl.uniprot.org/citations/9383054 | http://purl.uniprot.org/core/volume | "147"xsd:string |
| http://purl.uniprot.org/citations/9383054 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9383054 |
| http://purl.uniprot.org/citations/9383054 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9383054 |
| http://purl.uniprot.org/citations/9383054 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9383054 |
| http://purl.uniprot.org/citations/9383054 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9383054 |
| http://purl.uniprot.org/uniprot/Q93971 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/9383054 |
| http://purl.uniprot.org/uniprot/Q93971#attribution-02CF9FDD00C95E7D957B519E22EDEE38 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9383054 |