| http://purl.uniprot.org/citations/9393854 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9393854 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9393854 | http://www.w3.org/2000/01/rdf-schema#comment | "Invasion of human mucosal cells by N. gonorrhoeae via the binding to heparansulfate proteoglycan receptors is considered a crucial event of the infection. Using different human epithelial cells and primary fibroblasts, we show here an activation of the phosphatidylcholine-specific phospholipase C (PC-PLC) and acidic sphingomyelinase (ASM) by N. gonorrhoeae, resulting in the release of diacylglycerol and ceramide. Genetic and/or pharmacological blockade of ASM and PC-PLC cause inhibition of cellular invasion by N. gonorrhoeae. Complementation of ASM-deficient fibroblasts from Niemann-Pick disease patients restored N. gonorrhoeae-induced signaling and entry processes. The activation of PC-PLC and ASM, therefore, is an essential requirement for the entry of N. gonorrhoeae into distinct nonphagocytic human cell types including several epithelial cells and primary fibroblasts."xsd:string |
| http://purl.uniprot.org/citations/9393854 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)80448-1"xsd:string |
| http://purl.uniprot.org/citations/9393854 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)80448-1"xsd:string |
| http://purl.uniprot.org/citations/9393854 | http://purl.uniprot.org/core/author | "Meyer T.F."xsd:string |
| http://purl.uniprot.org/citations/9393854 | http://purl.uniprot.org/core/author | "Meyer T.F."xsd:string |
| http://purl.uniprot.org/citations/9393854 | http://purl.uniprot.org/core/author | "Lang F."xsd:string |
| http://purl.uniprot.org/citations/9393854 | http://purl.uniprot.org/core/author | "Lang F."xsd:string |
| http://purl.uniprot.org/citations/9393854 | http://purl.uniprot.org/core/author | "Sandhoff K."xsd:string |
| http://purl.uniprot.org/citations/9393854 | http://purl.uniprot.org/core/author | "Sandhoff K."xsd:string |
| http://purl.uniprot.org/citations/9393854 | http://purl.uniprot.org/core/author | "Ferlinz K."xsd:string |
| http://purl.uniprot.org/citations/9393854 | http://purl.uniprot.org/core/author | "Ferlinz K."xsd:string |
| http://purl.uniprot.org/citations/9393854 | http://purl.uniprot.org/core/author | "Grassme H."xsd:string |
| http://purl.uniprot.org/citations/9393854 | http://purl.uniprot.org/core/author | "Grassme H."xsd:string |
| http://purl.uniprot.org/citations/9393854 | http://purl.uniprot.org/core/author | "Gulbins E."xsd:string |
| http://purl.uniprot.org/citations/9393854 | http://purl.uniprot.org/core/author | "Gulbins E."xsd:string |
| http://purl.uniprot.org/citations/9393854 | http://purl.uniprot.org/core/author | "Brenner B."xsd:string |
| http://purl.uniprot.org/citations/9393854 | http://purl.uniprot.org/core/author | "Brenner B."xsd:string |
| http://purl.uniprot.org/citations/9393854 | http://purl.uniprot.org/core/author | "Harzer K."xsd:string |
| http://purl.uniprot.org/citations/9393854 | http://purl.uniprot.org/core/author | "Harzer K."xsd:string |
| http://purl.uniprot.org/citations/9393854 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9393854 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9393854 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/9393854 | http://purl.uniprot.org/core/name | "Cell"xsd:string |