| http://purl.uniprot.org/citations/9405468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9405468 | http://www.w3.org/2000/01/rdf-schema#comment | "The eukaryotic initiation factor 4E (eIF4E)-binding protein, PHAS-I, was phosphorylated rapidly and stoichiometrically when incubated with [gamma-32P]ATP and the mammalian target of rapamycin (mTOR) that had been immunoprecipitated with an antibody, mTAb1, directed against a region near the COOH terminus of mTOR. PHAS-I was phosphorylated more slowly by mTOR obtained either by immunoprecipitation with other antibodies or by affinity purification using a rapamycin/FKBP12 resin. Adding mTAb1 to either of these preparations of mTOR increased PHAS-I phosphorylation severalfold, indicating that mTAb1 activates the mTOR protein kinase. mTAb1-activated mTOR phosphorylated Thr36, Thr45, Ser64, Thr69, and Ser82 in PHAS-I. All five of these sites fit a (Ser/Thr)-Pro motif and are dephosphorylated in response to rapamycin in rat adipocytes. Thus, our findings indicate that Pro is a determinant of the mTOR protein kinase specificity and that mTOR contributes to the phosphorylation of PHAS-I in cells."xsd:string |
| http://purl.uniprot.org/citations/9405468 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.272.51.32547"xsd:string |
| http://purl.uniprot.org/citations/9405468 | http://purl.uniprot.org/core/author | "Lawrence J.C. Jr."xsd:string |
| http://purl.uniprot.org/citations/9405468 | http://purl.uniprot.org/core/author | "Haystead T.A."xsd:string |
| http://purl.uniprot.org/citations/9405468 | http://purl.uniprot.org/core/author | "Brunn G.J."xsd:string |
| http://purl.uniprot.org/citations/9405468 | http://purl.uniprot.org/core/author | "Fadden P."xsd:string |
| http://purl.uniprot.org/citations/9405468 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9405468 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/9405468 | http://purl.uniprot.org/core/pages | "32547-32550"xsd:string |
| http://purl.uniprot.org/citations/9405468 | http://purl.uniprot.org/core/title | "The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus."xsd:string |
| http://purl.uniprot.org/citations/9405468 | http://purl.uniprot.org/core/volume | "272"xsd:string |
| http://purl.uniprot.org/citations/9405468 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9405468 |
| http://purl.uniprot.org/citations/9405468 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9405468 |
| http://purl.uniprot.org/uniprot/#_Q62622-mappedCitation-9405468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9405468 |
| http://purl.uniprot.org/uniprot/Q62622 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9405468 |