| http://purl.uniprot.org/citations/9405645 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9405645 | http://www.w3.org/2000/01/rdf-schema#comment | "The development of two major subdivisions of the vertebrate nervous system, the midbrain and the cerebellum, is controlled by signals emanating from a constriction in the neural primordium called the midbrain/hindbrain organizer (Joyner, A. L. (1996) Trends Genet. 12, 15-201). The closely related transcription factors Pax-2 and Pax-5 exhibit an overlapping expression pattern very early in the developing midbrain/hindbrain junction. Experiments carried out in fish (Krauss, S., Maden, M., Holder, N. & Wilson, S. W. (1992) Nature (London) 360, 87-89) with neutralizing antibodies against Pax-b, the orthologue of Pax-2 in mouse, placed this gene family in an regulatory cascade necessary for the development of the midbrain and the cerebellum. The targeted mutation of Pax-5 has been reported to have only slight effects in the development of structures derived from the isthmic constriction, whereas the Pax-2 null mutant mice show a background-dependent phenotype with varying penetrance. To test a possible redundant function between Pax-2 and Pax-5 we analyzed the brain phenotypes of mice expressing different dosages of both genes. Our results demonstrate a conserved biological function of both proteins in midbrain/hindbrain regionalization. Additionally, we show that one allele of Pax-2, but not Pax-5, is necessary and sufficient for midbrain and cerebellum development in C57BL/6 mice."xsd:string |
| http://purl.uniprot.org/citations/9405645 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.94.26.14518"xsd:string |
| http://purl.uniprot.org/citations/9405645 | http://purl.uniprot.org/core/author | "Urbanek P."xsd:string |
| http://purl.uniprot.org/citations/9405645 | http://purl.uniprot.org/core/author | "Schwarz M."xsd:string |
| http://purl.uniprot.org/citations/9405645 | http://purl.uniprot.org/core/author | "Gruss P."xsd:string |
| http://purl.uniprot.org/citations/9405645 | http://purl.uniprot.org/core/author | "Busslinger M."xsd:string |
| http://purl.uniprot.org/citations/9405645 | http://purl.uniprot.org/core/author | "Alvarez-Bolado G."xsd:string |
| http://purl.uniprot.org/citations/9405645 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9405645 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/9405645 | http://purl.uniprot.org/core/pages | "14518-14523"xsd:string |
| http://purl.uniprot.org/citations/9405645 | http://purl.uniprot.org/core/title | "Conserved biological function between Pax-2 and Pax-5 in midbrain and cerebellum development: evidence from targeted mutations."xsd:string |
| http://purl.uniprot.org/citations/9405645 | http://purl.uniprot.org/core/volume | "94"xsd:string |
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