| http://purl.uniprot.org/citations/9406551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9406551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9406551 | http://www.w3.org/2000/01/rdf-schema#comment | "The crystal structure of an activation intermediate of human gastricsin has been determined at 2.4 A resolution. The human digestive enzyme gastricsin (pepsin C) is an aspartic proteinase that is synthesized as the inactive precursor (zymogen) progastricsin (pepsinogen C or hPGC). In the zymogen, a positively-charged N-terminal prosegment of 43 residues (Ala 1p-Leu 43p; the suffix 'p' refers to the prosegment) sterically prevents the approach of a substrate to the active site. Zymogen conversion occurs in an autocatalytic and stepwise fashion at low pH through the formation of intermediates. The structure of the non-covalent complex of a partially-cleaved peptide of the prosegment (Ala 1p-Phe 26p) with mature gastricsin (Ser 1-Ala 329) suggests an activation pathway that may be common to all gastric aspartic proteinases."xsd:string |
| http://purl.uniprot.org/citations/9406551 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsb1297-1010"xsd:string |
| http://purl.uniprot.org/citations/9406551 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsb1297-1010"xsd:string |
| http://purl.uniprot.org/citations/9406551 | http://purl.uniprot.org/core/author | "Cherney M.M."xsd:string |
| http://purl.uniprot.org/citations/9406551 | http://purl.uniprot.org/core/author | "Cherney M.M."xsd:string |
| http://purl.uniprot.org/citations/9406551 | http://purl.uniprot.org/core/author | "James M.N."xsd:string |
| http://purl.uniprot.org/citations/9406551 | http://purl.uniprot.org/core/author | "James M.N."xsd:string |
| http://purl.uniprot.org/citations/9406551 | http://purl.uniprot.org/core/author | "Khan A.R."xsd:string |
| http://purl.uniprot.org/citations/9406551 | http://purl.uniprot.org/core/author | "Khan A.R."xsd:string |
| http://purl.uniprot.org/citations/9406551 | http://purl.uniprot.org/core/author | "Tarasova N.I."xsd:string |
| http://purl.uniprot.org/citations/9406551 | http://purl.uniprot.org/core/author | "Tarasova N.I."xsd:string |
| http://purl.uniprot.org/citations/9406551 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9406551 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9406551 | http://purl.uniprot.org/core/name | "Nat. Struct. Biol."xsd:string |
| http://purl.uniprot.org/citations/9406551 | http://purl.uniprot.org/core/name | "Nat. Struct. Biol."xsd:string |
| http://purl.uniprot.org/citations/9406551 | http://purl.uniprot.org/core/pages | "1010-1015"xsd:string |
| http://purl.uniprot.org/citations/9406551 | http://purl.uniprot.org/core/pages | "1010-1015"xsd:string |
| http://purl.uniprot.org/citations/9406551 | http://purl.uniprot.org/core/title | "Structural characterization of activation 'intermediate 2' on the pathway to human gastricsin."xsd:string |
| http://purl.uniprot.org/citations/9406551 | http://purl.uniprot.org/core/title | "Structural characterization of activation 'intermediate 2' on the pathway to human gastricsin."xsd:string |
| http://purl.uniprot.org/citations/9406551 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/9406551 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/9406551 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9406551 |
| http://purl.uniprot.org/citations/9406551 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9406551 |