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| http://purl.uniprot.org/citations/9414479 | http://www.w3.org/2000/01/rdf-schema#comment | "The t haplotypes are variant alleles of genes in the proximal region of mouse Chromosome 17, linked together by four inversions. While females carrying two t haplotypes are fertile, males are sterile. Their spermatozoa exhibit severe motility defects and are unable to penetrate zona pellucida-free oocytes. Spermatozoa from males carrying one t haplotype (t/+) exhibit mild motility deficits and a delay in penetration of the zona-free oocyte. The inversions of the t haplotypes contain several genes that cause or contribute to male sterility, at least some of which can be identified by analysis of mice carrying Mus spretus-Mus domesticus recombinant Chromosomes 17. The t haplotypes specify a number of sperm biochemical abnormalities, but these have not been related directly to defects in fertilization. In t/+ males, spermatozoa not bearing the t haplotype are defective in fertilization compared with t-bearing spermatozoa. The mechanism causing this is likely to involve haploid gene expression confined to the t-bearing spermatids. Since many genes situated in the region of the t haplotypes have human homologues, an understanding of t haplotype sterility in mice is expected to contribute significantly to our knowledge of the genetic basis for human sperm dysfunction."xsd:string |
| http://purl.uniprot.org/citations/9414479 | http://purl.org/dc/terms/identifier | "doi:10.1530/ror.0.0020157"xsd:string |
| http://purl.uniprot.org/citations/9414479 | http://purl.uniprot.org/core/author | "Olds-Clarke P."xsd:string |
| http://purl.uniprot.org/citations/9414479 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9414479 | http://purl.uniprot.org/core/name | "Rev Reprod"xsd:string |
| http://purl.uniprot.org/citations/9414479 | http://purl.uniprot.org/core/pages | "157-164"xsd:string |
| http://purl.uniprot.org/citations/9414479 | http://purl.uniprot.org/core/title | "Models for male infertility: the t haplotypes."xsd:string |
| http://purl.uniprot.org/citations/9414479 | http://purl.uniprot.org/core/volume | "2"xsd:string |
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