http://purl.uniprot.org/citations/9418897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/9418897 | http://www.w3.org/2000/01/rdf-schema#comment | "The myb gene family consists of three members, named A-, B-, and c-myb. All three members of this family encode nuclear proteins that bind DNA in a sequence-specific manner and function as regulators of transcription. In this report, we have examined the biochemical and biological activities of murine B-myb and compared these properties with those of murine c-myb. In transient transactivation assays, murine B-myb exhibited transactivation potential comparable to that of c-myb. An analysis of deletion mutants of B-myb and c-myb showed that while the C-terminal domain of c-Myb acts as a negative regulator of transcriptional transactivation, the C-terminal domain of B-Myb functions as a positive enhancer of transactivation. To compare the biological activities of c-myb and B-myb, the two genes were overexpressed in 32Dcl3 cells, which are known to undergo terminal differentiation into granulocytes in the presence of granulocyte colony-stimulating factor (G-CSF). We observed that c-myb blocked the G-CSF-induced terminal differentiation of 32Dcl3 cells, resulting in their continued proliferation in the presence of G-CSF. In contrast, ectopic overexpression of B-myb blocked the ability of 32D cells to proliferate in the presence of G-CSF and accelerated the G-CSF-induced granulocytic differentiation of these cells. Similar studies with B-myb-c-myb chimeras showed that only chimeras that contained the C-terminal domain of B-Myb were able to accelerate the G-CSF-induced terminal differentiation of 32Dcl3 cells. These studies show that c-myb and B-myb do not exhibit identical biological activities and that the carboxyl-terminal regulatory domain of B-Myb plays a critical role in its biological function."xsd:string |
http://purl.uniprot.org/citations/9418897 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.18.1.499"xsd:string |
http://purl.uniprot.org/citations/9418897 | http://purl.uniprot.org/core/author | "Reddy E.P."xsd:string |
http://purl.uniprot.org/citations/9418897 | http://purl.uniprot.org/core/author | "Oh I.H."xsd:string |
http://purl.uniprot.org/citations/9418897 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
http://purl.uniprot.org/citations/9418897 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
http://purl.uniprot.org/citations/9418897 | http://purl.uniprot.org/core/pages | "499-511"xsd:string |
http://purl.uniprot.org/citations/9418897 | http://purl.uniprot.org/core/title | "The C-terminal domain of B-Myb acts as a positive regulator of transcription and modulates its biological functions."xsd:string |
http://purl.uniprot.org/citations/9418897 | http://purl.uniprot.org/core/volume | "18"xsd:string |
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