| http://purl.uniprot.org/citations/9419371 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9419371 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9419371 | http://www.w3.org/2000/01/rdf-schema#comment | "Gonadotropin-releasing hormone (GnRH) is a decapeptide widely known for its role in regulating reproduction by serving as a signal from the hypothalamus to pituitary gonadotropes. In addition to hypothalamic GnRH (GnRH-I), a second GnRH form (pGln-His-Trp-Ser-His-Gly-Trp-Tyr-Pro-Gly; GnRH-II) with unknown function has been localized to the midbrain of many vertebrates. We show here that a gene encoding GnRH-II is expressed in humans and is located on chromosome 20p13, distinct from the GnRH-I gene that is on 8p21-p11.2. The GnRH-II genomic and mRNA structures parallel those of GnRH-I. However, in contrast to GnRH-I, GnRH-II is expressed at significantly higher levels outside the brain (up to 30x), particularly in the kidney, bone marrow, and prostate. The widespread expression of GnRH-II suggests it may have multiple functions. Molecular phylogenetic analysis shows that this second gene is likely the result of a duplication before the appearance of vertebrates, and predicts the existence of a third GnRH form in humans and other vertebrates."xsd:string |
| http://purl.uniprot.org/citations/9419371 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.95.1.305"xsd:string |
| http://purl.uniprot.org/citations/9419371 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.95.1.305"xsd:string |
| http://purl.uniprot.org/citations/9419371 | http://purl.uniprot.org/core/author | "Eisen J.A."xsd:string |
| http://purl.uniprot.org/citations/9419371 | http://purl.uniprot.org/core/author | "Eisen J.A."xsd:string |
| http://purl.uniprot.org/citations/9419371 | http://purl.uniprot.org/core/author | "Fernald R.D."xsd:string |
| http://purl.uniprot.org/citations/9419371 | http://purl.uniprot.org/core/author | "Fernald R.D."xsd:string |
| http://purl.uniprot.org/citations/9419371 | http://purl.uniprot.org/core/author | "Kasten T.L."xsd:string |
| http://purl.uniprot.org/citations/9419371 | http://purl.uniprot.org/core/author | "Kasten T.L."xsd:string |
| http://purl.uniprot.org/citations/9419371 | http://purl.uniprot.org/core/author | "White R.B."xsd:string |
| http://purl.uniprot.org/citations/9419371 | http://purl.uniprot.org/core/author | "White R.B."xsd:string |
| http://purl.uniprot.org/citations/9419371 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9419371 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9419371 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/9419371 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/9419371 | http://purl.uniprot.org/core/pages | "305-309"xsd:string |
| http://purl.uniprot.org/citations/9419371 | http://purl.uniprot.org/core/pages | "305-309"xsd:string |
| http://purl.uniprot.org/citations/9419371 | http://purl.uniprot.org/core/title | "Second gene for gonadotropin-releasing hormone in humans."xsd:string |
| http://purl.uniprot.org/citations/9419371 | http://purl.uniprot.org/core/title | "Second gene for gonadotropin-releasing hormone in humans."xsd:string |
| http://purl.uniprot.org/citations/9419371 | http://purl.uniprot.org/core/volume | "95"xsd:string |
| http://purl.uniprot.org/citations/9419371 | http://purl.uniprot.org/core/volume | "95"xsd:string |
| http://purl.uniprot.org/citations/9419371 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9419371 |
| http://purl.uniprot.org/citations/9419371 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9419371 |