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http://purl.uniprot.org/citations/9425137http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9425137http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9425137http://www.w3.org/2000/01/rdf-schema#comment"We have identified a new Caenorhabditis elegans NK-2 class homeobox gene, designated ceh-24. Distinct cis-acting elements generate a complex neuronal and mesodermal expression pattern. A promoter-proximal enhancer mediates expression in a single pharyngeal muscle, the donut-shaped m8 cell at the posterior end of the pharynx. A second mesodermal enhancer is active in a set of eight nonstriated vulval muscles used in egg laying. Activation in the egg laying muscles requires an 'NdE-box' consensus motif (CATATG) which is related to, but distinct from, the standard E-box motif bound by the MyoD family of transcriptional activators. Ectodermal expression of ceh-24 is limited to a subset of sublateral motor neurons in the head of the animal; this activity requires a cis-acting activator element that is distinct from the control elements for pharyngeal and vulval muscle expression. Activation of ceh-24 in each of the three cell types coincides with the onset of differentiation. Using a set of transposon-induced null mutations, we show that ceh-24 is not essential for the formation of any of these cells. Although ceh-24 mutants have no evident defects under laboratory conditions, the pattern of ceh-24 activity is apparently important for Rhabditid nematodes: the related species C. briggsae contains a close homologue of C. elegans ceh-24 including a highly conserved and functionally equivalent set of cis-acting control signals."xsd:string
http://purl.uniprot.org/citations/9425137http://purl.org/dc/terms/identifier"doi:10.1242/dev.125.3.421"xsd:string
http://purl.uniprot.org/citations/9425137http://purl.org/dc/terms/identifier"doi:10.1242/dev.125.3.421"xsd:string
http://purl.uniprot.org/citations/9425137http://purl.uniprot.org/core/author"Fire A."xsd:string
http://purl.uniprot.org/citations/9425137http://purl.uniprot.org/core/author"Fire A."xsd:string
http://purl.uniprot.org/citations/9425137http://purl.uniprot.org/core/author"Harfe B.D."xsd:string
http://purl.uniprot.org/citations/9425137http://purl.uniprot.org/core/author"Harfe B.D."xsd:string
http://purl.uniprot.org/citations/9425137http://purl.uniprot.org/core/date"1998"xsd:gYear
http://purl.uniprot.org/citations/9425137http://purl.uniprot.org/core/date"1998"xsd:gYear
http://purl.uniprot.org/citations/9425137http://purl.uniprot.org/core/name"Development"xsd:string
http://purl.uniprot.org/citations/9425137http://purl.uniprot.org/core/name"Development"xsd:string
http://purl.uniprot.org/citations/9425137http://purl.uniprot.org/core/pages"421-429"xsd:string
http://purl.uniprot.org/citations/9425137http://purl.uniprot.org/core/pages"421-429"xsd:string
http://purl.uniprot.org/citations/9425137http://purl.uniprot.org/core/title"Muscle and nerve-specific regulation of a novel NK-2 class homeodomain factor in Caenorhabditis elegans."xsd:string
http://purl.uniprot.org/citations/9425137http://purl.uniprot.org/core/title"Muscle and nerve-specific regulation of a novel NK-2 class homeodomain factor in Caenorhabditis elegans."xsd:string
http://purl.uniprot.org/citations/9425137http://purl.uniprot.org/core/volume"125"xsd:string
http://purl.uniprot.org/citations/9425137http://purl.uniprot.org/core/volume"125"xsd:string
http://purl.uniprot.org/citations/9425137http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/9425137
http://purl.uniprot.org/citations/9425137http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/9425137
http://purl.uniprot.org/citations/9425137http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/9425137
http://purl.uniprot.org/citations/9425137http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/9425137
http://purl.uniprot.org/embl-cds/AAB86603.1http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/9425137
http://purl.uniprot.org/uniprot/O17319http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/9425137