| http://purl.uniprot.org/citations/9430655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9430655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9430655 | http://www.w3.org/2000/01/rdf-schema#comment | "We have identified the human homologue of a regulatory cofactor of Na(+)-H+ exchanger (NHE-RF) as a novel interactor for merlin, the neurofibromatosis 2 tumor suppressor protein. NHE-RF mediates protein kinase A regulation of Na(+)-H+ exchanger NHE3 to which it is thought to bind via one of its two PDZ domains. The carboxyl-terminal region of NHE-RF, downstream of the PDZ domains, interacts with the amino-terminal protein 4.1 domain-containing segment of merlin in yeast two-hybrid assays. This interaction also occurs in affinity binding assays with full-length NHE-RF expressed in COS-7 cells. NHE-RF binds to the related ERM proteins, moesin and radixin. We have localized human NHE-RF to actin-rich structures such as membrane ruffles, microvilli, and filopodia in HeLa and COS-7 cells, where it co-localizes with merlin and moesin. These findings suggest that hNHE-RF and its binding partners may participate in a larger complex (one component of which might be a Na(+)-H+ exchanger) that could be crucial for the actin filament assembly activated by the ERM proteins and for the tumor suppressor function of merlin."xsd:string |
| http://purl.uniprot.org/citations/9430655 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.3.1273"xsd:string |
| http://purl.uniprot.org/citations/9430655 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.3.1273"xsd:string |
| http://purl.uniprot.org/citations/9430655 | http://purl.uniprot.org/core/author | "Murthy A."xsd:string |
| http://purl.uniprot.org/citations/9430655 | http://purl.uniprot.org/core/author | "Murthy A."xsd:string |
| http://purl.uniprot.org/citations/9430655 | http://purl.uniprot.org/core/author | "Solomon F."xsd:string |
| http://purl.uniprot.org/citations/9430655 | http://purl.uniprot.org/core/author | "Solomon F."xsd:string |
| http://purl.uniprot.org/citations/9430655 | http://purl.uniprot.org/core/author | "Ramesh V."xsd:string |
| http://purl.uniprot.org/citations/9430655 | http://purl.uniprot.org/core/author | "Ramesh V."xsd:string |
| http://purl.uniprot.org/citations/9430655 | http://purl.uniprot.org/core/author | "Cordero E."xsd:string |
| http://purl.uniprot.org/citations/9430655 | http://purl.uniprot.org/core/author | "Cordero E."xsd:string |
| http://purl.uniprot.org/citations/9430655 | http://purl.uniprot.org/core/author | "Gusella J."xsd:string |
| http://purl.uniprot.org/citations/9430655 | http://purl.uniprot.org/core/author | "Gusella J."xsd:string |
| http://purl.uniprot.org/citations/9430655 | http://purl.uniprot.org/core/author | "Candia C."xsd:string |
| http://purl.uniprot.org/citations/9430655 | http://purl.uniprot.org/core/author | "Candia C."xsd:string |
| http://purl.uniprot.org/citations/9430655 | http://purl.uniprot.org/core/author | "Gonzalez-Agosti C."xsd:string |
| http://purl.uniprot.org/citations/9430655 | http://purl.uniprot.org/core/author | "Gonzalez-Agosti C."xsd:string |
| http://purl.uniprot.org/citations/9430655 | http://purl.uniprot.org/core/author | "Pinney D."xsd:string |
| http://purl.uniprot.org/citations/9430655 | http://purl.uniprot.org/core/author | "Pinney D."xsd:string |
| http://purl.uniprot.org/citations/9430655 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9430655 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9430655 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9430655 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |