| http://purl.uniprot.org/citations/9430685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9430685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9430685 | http://www.w3.org/2000/01/rdf-schema#comment | "Thyroid transcription factor-1 (TTF-1) is a homeodomain-containing transcription factor that is required for thyroid-specific expression of the thyroglobulin and thyroperoxidase genes as well as for lung-specific expression of the surfactant protein A, B, and C and the CC10 and the HNF-3 alpha genes. TTF-1 is a phosphoprotein, and the phosphorylation of TTF-1 has been studied already. However, the kinase(s) that could be responsible for this phosphorylation have not been known. In this paper we report the identification by in-gel kinase assay of a 56-kDa serine/threonine kinase that is able to phosphorylate TTF-1 in thyroid cells. The cloning of this kinase revealed that we had identified the rat homolog of the human MST2 kinase. The pathway in which human MST2 functions is not known; however, it does not appear to involve either mitogen-activated protein kinases such as Erk1 and Erk2 nor the stress-activated protein kinases such as JNK and p38. We show that the activity responsible for TTF-1 phosphorylation is constitutive in thyroid cells. Furthermore, we demonstrate that TTF-1 is phosphorylated in vivo by rMST2 at the same residues that had been identified previously as the major phosphorylation sites. Thus, TTF-1 represents the first identified target of this class of protein kinases."xsd:string |
| http://purl.uniprot.org/citations/9430685 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.3.1477"xsd:string |
| http://purl.uniprot.org/citations/9430685 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.3.1477"xsd:string |
| http://purl.uniprot.org/citations/9430685 | http://purl.uniprot.org/core/author | "Dilauro R."xsd:string |
| http://purl.uniprot.org/citations/9430685 | http://purl.uniprot.org/core/author | "Dilauro R."xsd:string |
| http://purl.uniprot.org/citations/9430685 | http://purl.uniprot.org/core/author | "Zannini M."xsd:string |
| http://purl.uniprot.org/citations/9430685 | http://purl.uniprot.org/core/author | "Zannini M."xsd:string |
| http://purl.uniprot.org/citations/9430685 | http://purl.uniprot.org/core/author | "Aurisicchio L."xsd:string |
| http://purl.uniprot.org/citations/9430685 | http://purl.uniprot.org/core/author | "Aurisicchio L."xsd:string |
| http://purl.uniprot.org/citations/9430685 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9430685 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9430685 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9430685 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9430685 | http://purl.uniprot.org/core/pages | "1477-1482"xsd:string |
| http://purl.uniprot.org/citations/9430685 | http://purl.uniprot.org/core/pages | "1477-1482"xsd:string |
| http://purl.uniprot.org/citations/9430685 | http://purl.uniprot.org/core/title | "Identification of the thyroid transcription factor 1 as a target for rat MST2 kinase."xsd:string |
| http://purl.uniprot.org/citations/9430685 | http://purl.uniprot.org/core/title | "Identification of the thyroid transcription factor 1 as a target for rat MST2 kinase."xsd:string |
| http://purl.uniprot.org/citations/9430685 | http://purl.uniprot.org/core/volume | "273"xsd:string |
| http://purl.uniprot.org/citations/9430685 | http://purl.uniprot.org/core/volume | "273"xsd:string |
| http://purl.uniprot.org/citations/9430685 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9430685 |
| http://purl.uniprot.org/citations/9430685 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9430685 |
| http://purl.uniprot.org/citations/9430685 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9430685 |
| http://purl.uniprot.org/citations/9430685 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9430685 |