| http://purl.uniprot.org/citations/9432982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9432982 | http://www.w3.org/2000/01/rdf-schema#comment | "Efficient loading of major histocompatibility complex class II molecules with peptides requires the invariant chain (Ii) and the class II-like molecule H-2M. Recent in vitro biochemical studies suggest that H2-M may function as a chaperone to rescue empty class II dimers. To test this hypothesis in vivo, we generated mice lacking both Ii and H-2M (Ii-/-M-/-). Antigen presenting cells (APCs) from Ii-/-M-/- mice, as compared with APCs from Ii-/-mice, exhibit a significant reduction in their ability to present self-peptides to a panel of class II I-Ab-restricted T cells. As a consequence of this defect in the loading of self peptides, CD4(+) thymocyte development is profoundly impaired in Ii-/-M-/-mice, resulting in a peripheral CD4(+) T cell population with low levels of T cell receptor expression. These findings are consistent with the idea that H-2M functions as a chaperone in the peptide loading of class II molecules in vivo."xsd:string |
| http://purl.uniprot.org/citations/9432982 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.187.2.245"xsd:string |
| http://purl.uniprot.org/citations/9432982 | http://purl.uniprot.org/core/author | "Eastman S."xsd:string |
| http://purl.uniprot.org/citations/9432982 | http://purl.uniprot.org/core/author | "Kovats S."xsd:string |
| http://purl.uniprot.org/citations/9432982 | http://purl.uniprot.org/core/author | "Rudensky A.Y."xsd:string |
| http://purl.uniprot.org/citations/9432982 | http://purl.uniprot.org/core/author | "Grubin C.E."xsd:string |
| http://purl.uniprot.org/citations/9432982 | http://purl.uniprot.org/core/author | "Van Kaer L."xsd:string |
| http://purl.uniprot.org/citations/9432982 | http://purl.uniprot.org/core/author | "Dongre A."xsd:string |
| http://purl.uniprot.org/citations/9432982 | http://purl.uniprot.org/core/author | "deRoos P."xsd:string |
| http://purl.uniprot.org/citations/9432982 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9432982 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/9432982 | http://purl.uniprot.org/core/pages | "245-251"xsd:string |
| http://purl.uniprot.org/citations/9432982 | http://purl.uniprot.org/core/title | "Invariant chain-independent function of H-2M in the formation of endogenous peptide-major histocompatibility complex class II complexes in vivo."xsd:string |
| http://purl.uniprot.org/citations/9432982 | http://purl.uniprot.org/core/volume | "187"xsd:string |
| http://purl.uniprot.org/citations/9432982 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9432982 |
| http://purl.uniprot.org/citations/9432982 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9432982 |
| http://purl.uniprot.org/uniprot/P28078#attribution-9E01A9EA92AEED500D0A7477CA71F0F6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9432982 |
| http://purl.uniprot.org/uniprot/P06343#attribution-42CB28BA83D2B010DF0D17C1893FF57A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9432982 |
| http://purl.uniprot.org/uniprot/P14483#attribution-42CB28BA83D2B010DF0D17C1893FF57A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9432982 |
| http://purl.uniprot.org/uniprot/P01921#attribution-42CB28BA83D2B010DF0D17C1893FF57A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9432982 |
| http://purl.uniprot.org/uniprot/P06342#attribution-42CB28BA83D2B010DF0D17C1893FF57A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9432982 |
| http://purl.uniprot.org/uniprot/P06345#attribution-42CB28BA83D2B010DF0D17C1893FF57A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9432982 |
| http://purl.uniprot.org/uniprot/P06346#attribution-42CB28BA83D2B010DF0D17C1893FF57A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9432982 |
| http://purl.uniprot.org/uniprot/P04227#attribution-42CB28BA83D2B010DF0D17C1893FF57A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9432982 |