| http://purl.uniprot.org/citations/9436978 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9436978 | http://www.w3.org/2000/01/rdf-schema#comment | "HIV-1 Vpr promotes nuclear entry of viral nucleic acids in nondividing macrophages and also causes a G2 cell-cycle arrest. Consistent with its role in nuclear transport, we show Vpr localizes to the nuclear envelope in both human and yeast cells. Like the importin-beta subunit of the nuclear import receptor, Vpr also interacts with the yeast importin-alpha subunit and nucleoporins. Moreover, overexpression of either Vpr or importin-beta in yeast blocks nuclear transport of mRNAs. A mutant form of Vpr (Vpr F34I) that does not localize at the nuclear envelope, or bind to importin-alpha and nucleoporins, renders HIV-1 incapable of infecting macrophages efficiently. Vpr F34I, however, still causes a G2 arrest, demonstrating that the dual functions of Vpr are genetically separable. Our data suggest Vpr functionally resembles importin-beta in nuclear import of the HIV-1 pre-integration complex and this function is essential for the role of Vpr in macrophage infection, but not G2 arrest."xsd:string |
| http://purl.uniprot.org/citations/9436978 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.12.2.175"xsd:string |
| http://purl.uniprot.org/citations/9436978 | http://purl.uniprot.org/core/author | "Silver P.A."xsd:string |
| http://purl.uniprot.org/citations/9436978 | http://purl.uniprot.org/core/author | "Emerman M."xsd:string |
| http://purl.uniprot.org/citations/9436978 | http://purl.uniprot.org/core/author | "Koepp D.M."xsd:string |
| http://purl.uniprot.org/citations/9436978 | http://purl.uniprot.org/core/author | "Vodicka M.A."xsd:string |
| http://purl.uniprot.org/citations/9436978 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9436978 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/9436978 | http://purl.uniprot.org/core/pages | "175-185"xsd:string |
| http://purl.uniprot.org/citations/9436978 | http://purl.uniprot.org/core/title | "HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection."xsd:string |
| http://purl.uniprot.org/citations/9436978 | http://purl.uniprot.org/core/volume | "12"xsd:string |
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