| http://purl.uniprot.org/citations/9437432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9437432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9437432 | http://www.w3.org/2000/01/rdf-schema#comment | "The crystal structure of the NF-kappa B p65 (RelA) homodimer in complex with a DNA target has been determined to 2.4 A resolution. The two p65 subunits are not symmetrically disposed on the DNA target. The homodimer should optimally bind to a pseudo-palindromic nine base pair target with each subunit recognizing a 5'GGAA-3' half site separated by a central A-T base pair. However, one of the subunits (subunit B) encounters a half site of 5'-GAAA-3'. The single base-pair change from G-C to A-T results in highly unfavorable interactions between this half site and the base contacting protein residues in subunit B, which leads to an 18 degrees rotation of the N-terminal terminal domain from its normal conformation. Remarkably, subunit B retains all the interactions with the sugar phosphate backbone of the DNA target. This mode of interaction allows the NF-kappa B p65 homodimer to recognize DNA targets containing only one cognate half site. Differences in the sequence of the other half site provide variations in conformation and affinity of the complex."xsd:string |
| http://purl.uniprot.org/citations/9437432 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsb0198-67"xsd:string |
| http://purl.uniprot.org/citations/9437432 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsb0198-67"xsd:string |
| http://purl.uniprot.org/citations/9437432 | http://purl.uniprot.org/core/author | "Ghosh S."xsd:string |
| http://purl.uniprot.org/citations/9437432 | http://purl.uniprot.org/core/author | "Ghosh S."xsd:string |
| http://purl.uniprot.org/citations/9437432 | http://purl.uniprot.org/core/author | "Chen Y.Q."xsd:string |
| http://purl.uniprot.org/citations/9437432 | http://purl.uniprot.org/core/author | "Chen Y.Q."xsd:string |
| http://purl.uniprot.org/citations/9437432 | http://purl.uniprot.org/core/author | "Ghosh G."xsd:string |
| http://purl.uniprot.org/citations/9437432 | http://purl.uniprot.org/core/author | "Ghosh G."xsd:string |
| http://purl.uniprot.org/citations/9437432 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9437432 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9437432 | http://purl.uniprot.org/core/name | "Nat. Struct. Biol."xsd:string |
| http://purl.uniprot.org/citations/9437432 | http://purl.uniprot.org/core/name | "Nat. Struct. Biol."xsd:string |
| http://purl.uniprot.org/citations/9437432 | http://purl.uniprot.org/core/pages | "67-73"xsd:string |
| http://purl.uniprot.org/citations/9437432 | http://purl.uniprot.org/core/pages | "67-73"xsd:string |
| http://purl.uniprot.org/citations/9437432 | http://purl.uniprot.org/core/title | "A novel DNA recognition mode by the NF-kappa B p65 homodimer."xsd:string |
| http://purl.uniprot.org/citations/9437432 | http://purl.uniprot.org/core/title | "A novel DNA recognition mode by the NF-kappa B p65 homodimer."xsd:string |
| http://purl.uniprot.org/citations/9437432 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/9437432 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/9437432 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9437432 |
| http://purl.uniprot.org/citations/9437432 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9437432 |
| http://purl.uniprot.org/citations/9437432 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9437432 |
| http://purl.uniprot.org/citations/9437432 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9437432 |