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http://purl.uniprot.org/citations/9438848 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitogen stimulation of cytoskeletal changes and c-jun amino-terminal kinases is mediated by Rac small guanine nucleotide-binding proteins. Vav, a guanosine diphosphate (GDP)-guanosine triphosphate (GTP) exchange factor for Rac that stimulates the exchange of bound GDP for GTP, bound to and was directly controlled by substrates and products of phosphoinositide (PI) 3-kinase. The PI 3-kinase substrate phosphatidylinositol-4,5-bisphosphate inhibited activation of Vav by the tyrosine kinase Lck, whereas the product phosphatidylinositol-3,4,5-trisphosphate enhanced phosphorylation and activation of Vav by Lck. Control of Vav in response to mitogens by the products of PI 3-kinase suggests a mechanism for Ras-dependent activation of Rac."xsd:string |
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http://purl.uniprot.org/citations/9438848 | http://purl.uniprot.org/core/author | "Han J."xsd:string |
http://purl.uniprot.org/citations/9438848 | http://purl.uniprot.org/core/author | "Das B."xsd:string |
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http://purl.uniprot.org/citations/9438848 | http://purl.uniprot.org/core/author | "Shu X."xsd:string |
http://purl.uniprot.org/citations/9438848 | http://purl.uniprot.org/core/author | "Falck J.R."xsd:string |
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http://purl.uniprot.org/citations/9438848 | http://purl.uniprot.org/core/author | "Mosteller R.D."xsd:string |
http://purl.uniprot.org/citations/9438848 | http://purl.uniprot.org/core/author | "Krishna U.M."xsd:string |
http://purl.uniprot.org/citations/9438848 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
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http://purl.uniprot.org/citations/9438848 | http://purl.uniprot.org/core/title | "Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav."xsd:string |
http://purl.uniprot.org/citations/9438848 | http://purl.uniprot.org/core/volume | "279"xsd:string |
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