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http://purl.uniprot.org/citations/9438848http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9438848http://www.w3.org/2000/01/rdf-schema#comment"Mitogen stimulation of cytoskeletal changes and c-jun amino-terminal kinases is mediated by Rac small guanine nucleotide-binding proteins. Vav, a guanosine diphosphate (GDP)-guanosine triphosphate (GTP) exchange factor for Rac that stimulates the exchange of bound GDP for GTP, bound to and was directly controlled by substrates and products of phosphoinositide (PI) 3-kinase. The PI 3-kinase substrate phosphatidylinositol-4,5-bisphosphate inhibited activation of Vav by the tyrosine kinase Lck, whereas the product phosphatidylinositol-3,4,5-trisphosphate enhanced phosphorylation and activation of Vav by Lck. Control of Vav in response to mitogens by the products of PI 3-kinase suggests a mechanism for Ras-dependent activation of Rac."xsd:string
http://purl.uniprot.org/citations/9438848http://purl.org/dc/terms/identifier"doi:10.1126/science.279.5350.558"xsd:string
http://purl.uniprot.org/citations/9438848http://purl.uniprot.org/core/author"Han J."xsd:string
http://purl.uniprot.org/citations/9438848http://purl.uniprot.org/core/author"Das B."xsd:string
http://purl.uniprot.org/citations/9438848http://purl.uniprot.org/core/author"Xia Y."xsd:string
http://purl.uniprot.org/citations/9438848http://purl.uniprot.org/core/author"Shu X."xsd:string
http://purl.uniprot.org/citations/9438848http://purl.uniprot.org/core/author"Falck J.R."xsd:string
http://purl.uniprot.org/citations/9438848http://purl.uniprot.org/core/author"Broek D."xsd:string
http://purl.uniprot.org/citations/9438848http://purl.uniprot.org/core/author"White M.A."xsd:string
http://purl.uniprot.org/citations/9438848http://purl.uniprot.org/core/author"Luby-Phelps K."xsd:string
http://purl.uniprot.org/citations/9438848http://purl.uniprot.org/core/author"Mosteller R.D."xsd:string
http://purl.uniprot.org/citations/9438848http://purl.uniprot.org/core/author"Krishna U.M."xsd:string
http://purl.uniprot.org/citations/9438848http://purl.uniprot.org/core/date"1998"xsd:gYear
http://purl.uniprot.org/citations/9438848http://purl.uniprot.org/core/name"Science"xsd:string
http://purl.uniprot.org/citations/9438848http://purl.uniprot.org/core/pages"558-560"xsd:string
http://purl.uniprot.org/citations/9438848http://purl.uniprot.org/core/title"Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav."xsd:string
http://purl.uniprot.org/citations/9438848http://purl.uniprot.org/core/volume"279"xsd:string
http://purl.uniprot.org/citations/9438848http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/9438848
http://purl.uniprot.org/citations/9438848http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/9438848
http://purl.uniprot.org/uniprot/#_A0A0A0MR07-mappedCitation-9438848http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9438848
http://purl.uniprot.org/uniprot/#_P52735-mappedCitation-9438848http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9438848
http://purl.uniprot.org/uniprot/#_A0A2X0SZ57-mappedCitation-9438848http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9438848
http://purl.uniprot.org/uniprot/#_B2R8B5-mappedCitation-9438848http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9438848
http://purl.uniprot.org/uniprot/#_E9PXI0-mappedCitation-9438848http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9438848