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| http://purl.uniprot.org/citations/9438849 | http://www.w3.org/2000/01/rdf-schema#comment | "The Son of Sevenless (Sos) proteins control receptor-mediated activation of Ras by catalyzing the exchange of guanosine diphosphate for guanosine triphosphate on Ras. The NH2-terminal region of Sos contains a Dbl homology (DH) domain in tandem with a pleckstrin homology (PH) domain. In COS-1 cells, the DH domain of Sos stimulated guanine nucleotide exchange on Rac but not Cdc42 in vitro and in vivo. The tandem DH-PH domain of Sos (DH-PH-Sos) was defective in Rac activation but regained Rac stimulating activity when it was coexpressed with activated Ras. Ras-mediated activation of DH-PH-Sos did not require activation of mitogen-activated protein kinase but it was dependent on activation of phosphoinositide 3-kinase. These results reveal a potential mechanism for coupling of Ras and Rac signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/9438849 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.279.5350.560"xsd:string |
| http://purl.uniprot.org/citations/9438849 | http://purl.uniprot.org/core/author | "Bar-Sagi D."xsd:string |
| http://purl.uniprot.org/citations/9438849 | http://purl.uniprot.org/core/author | "Yatsula B.A."xsd:string |
| http://purl.uniprot.org/citations/9438849 | http://purl.uniprot.org/core/author | "Nimnual A.S."xsd:string |
| http://purl.uniprot.org/citations/9438849 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9438849 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/9438849 | http://purl.uniprot.org/core/pages | "560-563"xsd:string |
| http://purl.uniprot.org/citations/9438849 | http://purl.uniprot.org/core/title | "Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos."xsd:string |
| http://purl.uniprot.org/citations/9438849 | http://purl.uniprot.org/core/volume | "279"xsd:string |
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