| http://purl.uniprot.org/citations/9440710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9440710 | http://www.w3.org/2000/01/rdf-schema#comment | "Tropomyosin (TM) is an integral component of the thin filament in muscle fibers and is involved in regulating actin-myosin interactions. TM is encoded by a family of four alternatively spliced genes that display highly conserved nucleotide and amino acid sequences. To assess the functional and developmental significance of alpha-TM, the murine alpha-TM gene was disrupted by homologous recombination. Homozygous alpha-TM null mice are embryonic lethal, dying between 8 and 11.5 days post coitum. Mice that are heterozygous for alpha-TM are viable and reproduce normally. Heterozygous knockout mouse hearts show a 50% reduction in cardiac muscle alpha-TM mRNA, with no compensatory increase in transcript levels by striated muscle beta-TM or TM-30 isoforms. Surprisingly, this reduction in alpha-TM mRNA levels in heterozygous mice is not reflected at the protein level, where normal amounts of striated muscle alpha-TM protein are produced and integrated in the myofibril. Quantification of alpha-TM mRNA bound in polysomal fractions reveals that both wild-type and heterozygous knockout animals have similar levels. These data suggest that a change in steady-state level of alpha-TM mRNA does not affect the relative amount of mRNA translated and amount of protein synthesized. Physiological analyses of myocardial and myofilament function show no differences between heterozygous alpha-TM mice and control mice. The present study suggests that translational regulation plays a major role in the control of TM expression."xsd:string |
| http://purl.uniprot.org/citations/9440710 | http://purl.org/dc/terms/identifier | "doi:10.1161/01.res.82.1.116"xsd:string |
| http://purl.uniprot.org/citations/9440710 | http://purl.uniprot.org/core/author | "Evans C."xsd:string |
| http://purl.uniprot.org/citations/9440710 | http://purl.uniprot.org/core/author | "Boivin G."xsd:string |
| http://purl.uniprot.org/citations/9440710 | http://purl.uniprot.org/core/author | "Muthuchamy M."xsd:string |
| http://purl.uniprot.org/citations/9440710 | http://purl.uniprot.org/core/author | "Wieczorek D.F."xsd:string |
| http://purl.uniprot.org/citations/9440710 | http://purl.uniprot.org/core/author | "Solaro R.J."xsd:string |
| http://purl.uniprot.org/citations/9440710 | http://purl.uniprot.org/core/author | "Wolska B.M."xsd:string |
| http://purl.uniprot.org/citations/9440710 | http://purl.uniprot.org/core/author | "Hewett T."xsd:string |
| http://purl.uniprot.org/citations/9440710 | http://purl.uniprot.org/core/author | "Rethinasamy P."xsd:string |
| http://purl.uniprot.org/citations/9440710 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9440710 | http://purl.uniprot.org/core/name | "Circ Res"xsd:string |
| http://purl.uniprot.org/citations/9440710 | http://purl.uniprot.org/core/pages | "116-123"xsd:string |
| http://purl.uniprot.org/citations/9440710 | http://purl.uniprot.org/core/title | "Molecular and physiological effects of alpha-tropomyosin ablation in the mouse."xsd:string |
| http://purl.uniprot.org/citations/9440710 | http://purl.uniprot.org/core/volume | "82"xsd:string |
| http://purl.uniprot.org/citations/9440710 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9440710 |
| http://purl.uniprot.org/citations/9440710 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9440710 |
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