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http://purl.uniprot.org/citations/9442388http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9442388http://www.w3.org/2000/01/rdf-schema#comment"In order to elucidate the role of NF-ATp, one of the most prominent members of family of NF-AT transcription factors in peripheral T lymphocytes, in T cell activation and differentiation we created NF-ATp-deficient mice by gene targeting. Such NF-ATp-/-mice are born and appear to develop a normal immune system. Apart from clear-cut defects in the synthesis of mRNAs for Th2-type lymphokines, such as IL-4, IL-5, IL-10 and IL-13, in primary and secondary stimulations of spleen cells in vitro, of a distinct impaired deletion of V beta 11+/CD4+ T lymphocytes from these mice was detected after superantigen injection. Moreover, NF-ATp-/-mice older than 6 weeks show an 2-5 fold increase in number of lymphocytes. This is correlated with an increased expression of activation markers CD44 and CD69 and decreased expression of CD62."xsd:string
http://purl.uniprot.org/citations/9442388http://purl.org/dc/terms/identifier"doi:10.1016/s0171-2985(97)80037-x"xsd:string
http://purl.uniprot.org/citations/9442388http://purl.uniprot.org/core/author"Jankevics E."xsd:string
http://purl.uniprot.org/citations/9442388http://purl.uniprot.org/core/author"Schuh K."xsd:string
http://purl.uniprot.org/citations/9442388http://purl.uniprot.org/core/author"Schimpl A."xsd:string
http://purl.uniprot.org/citations/9442388http://purl.uniprot.org/core/author"Serfling E."xsd:string
http://purl.uniprot.org/citations/9442388http://purl.uniprot.org/core/author"Siebelt F."xsd:string
http://purl.uniprot.org/citations/9442388http://purl.uniprot.org/core/author"Heyer J."xsd:string
http://purl.uniprot.org/citations/9442388http://purl.uniprot.org/core/author"Kneitz B."xsd:string
http://purl.uniprot.org/citations/9442388http://purl.uniprot.org/core/date"1997"xsd:gYear
http://purl.uniprot.org/citations/9442388http://purl.uniprot.org/core/name"Immunobiology"xsd:string
http://purl.uniprot.org/citations/9442388http://purl.uniprot.org/core/pages"162-169"xsd:string
http://purl.uniprot.org/citations/9442388http://purl.uniprot.org/core/title"Inefficient termination of antigen responses in NF-ATp-deficient mice."xsd:string
http://purl.uniprot.org/citations/9442388http://purl.uniprot.org/core/volume"198"xsd:string
http://purl.uniprot.org/citations/9442388http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/9442388
http://purl.uniprot.org/citations/9442388http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/9442388
http://purl.uniprot.org/uniprot/#_A2AQC8-mappedCitation-9442388http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9442388
http://purl.uniprot.org/uniprot/#_B5B2P6-mappedCitation-9442388http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9442388
http://purl.uniprot.org/uniprot/#_B5B2P7-mappedCitation-9442388http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9442388
http://purl.uniprot.org/uniprot/#_B5B2P8-mappedCitation-9442388http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9442388
http://purl.uniprot.org/uniprot/#_B5B2Q2-mappedCitation-9442388http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9442388
http://purl.uniprot.org/uniprot/#_B5B2Q4-mappedCitation-9442388http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9442388
http://purl.uniprot.org/uniprot/#_B5B2Q6-mappedCitation-9442388http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9442388
http://purl.uniprot.org/uniprot/#_B5B2Q8-mappedCitation-9442388http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9442388